Fig. 5
Multiple factor analysis projection plot at T1 in an independent cohort of 31 animals. a The first two axes of MFA represent metabolome, transcriptome, and miRNome data sets at T1. Different shapes and colors represent the respective “omic” data sets, which are connected by lines where the length of the line is proportional to the divergence between the data from a same animal. Lines are joined by a common point, representing the reference structure, which maximizes covariance derived from the MFA synthetic analysis. b Summarization of the concordance between “omic” data sets on the space. c Data sets are shown in the different dimensions while showing the contribution of each eigenvalue to the total variance; d Boxplot of the expression of the molecules having high weights (|r2| > 0.80) on the PC1 of MFA; e Boxplot of the expression of genes having high weights (|r2| > 0.80) on the PC2 of MFA. In all cases, to ensure that expression levels of the animals in the validation set confirmed those of the experimental set, for each molecule, expression levels of animals from the validation set (cyan color) and experimental set (dark green color) are plotted