Fig. 2
From: Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways
Sequence analysis of INTS12’s PHD and its sequence similarity to epigenetic regulators of gene expression. a Quantitative assessment of INTS12 conservation using a repertoire of 66 metazoan open reading frames. The ratio of non-synonymous changes to synonymous changes (dN/dS) is shown throughout the protein. dN/dS approaching zero indicate strong and significant conservation (n = 66 species): red colour P < 0.1, blue colour P > 0.1. P-value represents the probability of observed dN/dS ratio given the null the hypothesis of neutral evolution. b Full length INTS12 protein sequence (NP_001135943.1) BLASTP against a database of Homo sapiens protein sequences shows the sequence similarity to be exclusively within the PHD. PHD appears as a putative zinc and histone H3 binding site