Fig. 4

Comparison of the DNA methylation status between the ESCs and other cell types. a: Scatterplots of the beta-values in the ESCs and other cell types. The DNA methylation statuses of the genes whose average beta-value from − 300 to + 700 bp in the ESCs was less than 0.2 and whose expression were increased or decreased more than 1.5-fold during decidualization were compared between the ESCs and other cell types (human embryonic stem cells, brain, liver, omentum, pancreas, spleen, saliva and leukocyte). The average beta-values from − 300 to + 700 bp are plotted according to the beta-values of the ESCs (horizontal axis) and other cell types (vertical axis). Dashed lines show minimum beta-value changes of 0.30. Red dots indicate the genes that are differentially DNA hypermethylated (Δbeta-values > 0.3) genes in other cell types compared to the ESCs. b: Up-regulated and down-regulated genes are classified into 3 groups based on the specificity of the DNA hypomethylation in the ESCs. ESC-specific genes indicate the genes that are less methylated in the ESCs than any other cell types. Non-ESC-specific genes indicate the genes in which one or more cell types show DNA hypomethylation similar to the ESCs