Table 1 Distribution patterns of pfcrt and pfmdr1 polymorphisms in P. falciparum isolates collected during period 1 (1993–1998) and period 2 (2002–2008). Data are presented as percent and (number)
Gene | Codon | Genotype | Prevalence (n) | p-value | |
|---|---|---|---|---|---|
Period 1 | Period 2 | ||||
Pfcrt | 76 | Mutant | 97.9% (137) | 97.1% (401) | 0.448 |
Wild-type | 2.1% (3) | 2.9% (12) | |||
220 | Mutant | 97.9% (140) | 99.4% (171) | 0.245 | |
Wild-type | 2.1% (3) | 1.0% (2) | |||
271 | Mutant | 97.2% (139) | 97.1% (333) | 0.943 | |
Wild-type | 2.8% (4) | 2.9% (10) | |||
326 | Mutant | 98.6% (140) | 99.7% (385) | 0.119 | |
Wild-type | 1.4% (2) | 0.3% (1) | |||
356 | Mutant | 96.4% (134) | 98.2% (378) | 0.229 | |
Wild-type | 3.6% (5) | 1.8% (7) | |||
371 | Mutant | 97.8% (136) | 98.9% (375) | 0.335 | |
Wild-type | 2.2% (3) | 1.1% (4) | |||
Pfmdr1 | 86 | Mutant | 7.1% (10) | 3.1% (12) | 0.038* |
Wild-type | 92.9% (130) | 96.9% (379) | |||
Copy number | 1 copy | 65.7% (90) | 87.8% (390) | < 0.0001* | |
2 copies | 18.2% (25) | 6.3% (28) | |||
3 copies | 5.1% (7) | 1.4% (6) | |||
≥ 4 copies | 10.9% (15) | 4.5% (20) | |||