Fig. 2

Serine-driven 1C and folate metabolism. Accession numbers of B. nonstop homologs are listed in Table S7. Numbers in colors represent proteins with predicted targeting signal (mitochondrial, blue; no signal; white). Numbers and arrows in light-grey represent enzymes that were not identified. Enzymes: 1, L-threonine 3-dehydrogenase; 2, glycine-C-acetyl transferase; 3, glycine cleavage system; 4; serine hydroxymethyltransferase; 5, dihydrofolate reductase-thymidylate synthase; 6, C-1-tetrahydrofolate synthase; 7, thiopurine S-methyltransferase; 8; 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase; 9, methionyl-tRNA synthetase; 10, methionyl-tRNA formyltransferase