Whole transcriptomic analysis reveals overexpression of salivary gland and cuticular proteins genes in insecticide-resistant Anopheles arabiensis from Western Kenya

Table 1 Results showing summaries of differential gene expression patterns of An. arabiensis for alphacypermethrin, deltamethrin and pirimiphos-methyl. Genes that were significantly differentially expressed at p < 0.01 and fold change (FC) > 2 were considered as candidate genes of interest

Sample ID	No. of genes tested	DE genes (adjP < 0.01)		DE genes(\|FC\|> 2 adjP < 0.01)
Sample ID	No. of genes tested	Up	Down	Up	Down
SA vs SU	9984	42	45	26	37
SD vs SU	10,006	34	42	26	34
SP vs SU	10,217	84	43	42	26
SA vs DO	10,217	1501	1202	838	387
SD vs DO	10,231	1764	1118	856	331
SP vs DO	10,386	2096	1923	987	509
SU vs DO	10,265	1089	617	815	340
MA vs MU	9707	933	764	160	157
MD vs MU	9626	204	296	117	201
MP vs MU	9814	980	1138	193	164
MA vs DO	10,217	1495	820	795	293
MD vs DO	10,204	833	374	657	249
MP vs DO	10,249	1982	1741	1007	500
MU vs DO	10,158	1570	1554	630	471

SA Siaya alpha-cypermethrin, SD Siaya deltamethrin, SP Siaya pirimiphos-methyl, SU Siaya unexposed, MA Migori alpha-cypermethrin, MD Migori deltamethrin, MP Migori primiphos-methyl, MU Migori unexposed, DO Dongola (An. arabiensis reference susceptible strain), DE differentially expressed, FC Fold change, adjP P-value adjusted for multiple testing by the method of Benjamini and Hochberg 1995

ISSN: 1471-2164