Fig. 1

Schematic overview: study design for identification of type-specific EBNA2 binding events and binding partners. Starting with two human B cell lines with type 1 EBV infection and two human B cell lines with type 2 EBV infection, we performed EBNA2 chromatin immunoprecipitation (ChIP-seq). Using these data, we identified shared and type-specific EBNA2 ChIP-seq peaks in the human genome. Differential EBNA2 interactions with human cofactors were predicted computationally and validated experimentally