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Table 2 Characteristics of key modules in the PPI network common to cattle, sheep, and pigs

From: Network visualization of genes involved in skeletal muscle myogenesis in livestock animals

Module

Genes

P-value

GO terms

KEGG pathways

A

TNC, PPARGC1A, CFB, VEGFA, DKK3, CAV1, SERPINA1, VWF, MITF, NOS3, ETS2, FOS, TIE1, PTGDS, FLT1, AURKA, MBP, IGF2R, CDH1, IGFBP2, EGFR, TINAGL1

1.315*106

GO:0043406 ~ positive regulation of MAP kinase activity (FLT1, EGFR, VEGFA); GO:0048010 ~ vascular endothelial growth factor receptor signaling pathway (FLT1, VEGFA);

bta04510:Focal adhesion (FLT1, VWF, CAV1, TNC, EGFR, VEGFA); bta04151:PI3K-Akt signaling pathway (FLT1, VWF, NOS3, TNC, EGFR, VEGFA); bta04066:HIF-1 signaling pathway (FLT1, NOS3, EGFR, VEGFA); bta04015:Rap1 signaling pathway (FLT1, CDH1, EGFR, VEGFA); bta04014: Ras signaling pathway (FLT1, EGFR, ETS2, VEGFA); bta04010:MAPK signaling pathway (FLT1, FOS, EGFR, VEGFA)

B

SPG21, PPARGC1A, MYH2, GPD2, MYL4, ATP2A1, TYMS, SLC2A4, NOS3, ENO3, NAMPT, AGPAT1, TST, SLC25A4, FABP5, CPT1B, ACSL1, ME, ALDH1A1, SQLE

5.369*106

 

bta03320:PPAR signaling pathway (FABP5, ACSL1, ME1, CPT1B); bta04931: Insulin resistance (NOS3, SLC2A4, CPT1B, PPARGC1A); bta04152:AMPK signaling pathway (SLC2A4, CPT1B, PPARGC1A)

C

PPARGC1A, CFB, VEGFA, CAV1, SERPINA1, VWF, MAFB, MITF, NOS3, ETS2, FOS, ZFP36, TIE1, FLT1, AURKA, MBP, IGF2R, CDH1, IGFBP2

1.626*105

GO:0043406 ~ positive regulation of MAP kinase activity (FLT1, EGFR, VEGFA);

GO:0048010 ~ vascular endothelial growth factor receptor signaling pathway (FLT1, VEGFA)

bta04510:Focal adhesion (FLT1, VWF, CAV1, EGFR, VEGFA); bta04066:HIF-1 signaling pathway (FLT1, NOS3, EGFR, VEGFA); bta04151:PI3K-Akt signaling pathway (FLT1, VWF, NOS3, EGFR, VEGFA); bta04015:Rap1 signaling pathway (FLT1, CDH1, EGFR, VEGFA); bta04010: MAPK signaling pathway (FLT1, FOS, EGFR, VEGFA)

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BMC Genomics

ISSN: 1471-2164

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