Table 3 GO annotation and KEGG enrichment of genes interacting with hub genes
From: Network visualization of genes involved in skeletal muscle myogenesis in livestock animals
Hub gene | Genes | GO terms | KEGG pathways |
|---|---|---|---|
EGFR | AREG, BTC, CBL, EGFR, EREG, GRB2 | GO:0007173 ~ Epidermal growth factor receptor signaling pathway, GO:0007176 ~ Regulation of epidermal growth factor-activated receptor activity, GO:0045741 ~ Positive regulation of epidermal growth factor-activated receptor activity, GO:0007275 ~ Multicellular organism development, GO:0008286 ~ Insulin receptor signaling pathway | bta04014: Ras signaling pathway, bta04010: MAPK signaling pathway, bta04151: PI3K-Akt signaling pathway, bta04068: FoxO signaling pathway, bta04910: Insulin signaling pathway, bta04510: Focal adhesion |
VEGFA | ANGPT2, ENSBTAP00000007026, FLT1, FLT4, FN1, HIF1A, KDR, NRP1, NRP2, TEK, VEGFA | GO:0038084 ~ Vascular endothelial growth factor signaling pathway, GO:0048010 ~ Vascular endothelial growth factor receptor signaling pathway | bta04151: PI3K-Akt signaling pathway, bta04015: Rap1 signaling pathway, bta04014: Ras signaling pathway, bta04010: MAPK signaling pathway, bta04066: HIF-1 signaling pathway, bta04510: Focal adhesion |
CDH1 | CDH1, CTNNA1, CTNNB1, CTNND1, EGFR, IQGAP1, ITGAE, JUP, MET, SRC, VCL | GO:0071363 ~ Cellular response to growth factor stimulus | bta04015:Rap1 signaling pathway, bta04510: Focal adhesion |
CAV1 | CALM2, CAV1, CAV2, EGFR, ESR1, FLNA, FYN, ITGB1 | - | bta04510:Focal adhesion, bta04015: Rap1 signaling pathway, bta04014: Ras signaling pathway, bta04151: PI3K-Akt signaling pathway, bta04066: HIF-1 signaling pathway |
SLC2A4 | AKT1, INS, IRS1, RAB10, RAB14, RAB8A, SLC2A4, STX4, TBC1D1, TBC1D4, VAMP2 | - | bta04152: AMPK signaling pathway, bta04931: Insulin resistance, bta04068: FoxO signaling pathway, bta04910: Insulin signaling pathway, bta04911: Insulin secretion |