Skip to main content

Table 2 Hazard ratio (95%CI) of atrial fibrillation with different electrolytes levels

From: Serum electrolyte concentrations and risk of atrial fibrillation: an observational and mendelian randomization study

 

Range, mmol/L; mg/dL

No. of events (%)

Unadjusted

Adjusted model 1a

Adjusted model 2b

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Potassium

< 5th

2.50–3.59

146 (19.84)

1.38 (1.15,1.66)

0.001

1.56 (1.29,1.89)

< 0.001

1.37 (1.13,1.66)

0.001

5 to < 20th

3.60–4.09

386 (17.48)

1.05 (0.92,1.21)

0.45

1.12 (0.98,1.29)

0.11

1.08 (0.94,1.24)

0.25

20 to < 40th

4.10–4.29

493 (16.75)

1.01 (0.89,1.14)

0.93

1.03 (0.91,1.17)

0.61

1.04 (0.91,1.18)

0.57

40 to < 60th

4.30–4.49

489 (16.60)

1.00 (Reference)

–

1.00 (Reference)

–

1.00 (Reference)

–

60 to < 80th

4.50–4.79

506 (17.19)

1.07 (0.94,1.21)

0.32

1.01 (0.89,1.14)

0.91

1.01 (0.89,1.15)

0.85

80 to < 95th

4.80–5.19

394 (17.84)

1.09 (0.96,1.25)

0.19

1.04 (0.90,1.19)

0.61

1.06 (0.93,1.21)

0.40

≥ 95th

5.20–6.50

125 (16.98)

1.08 (0.89,1.32)

0.44

1.00 (0.82,1.21)

0.96

1.02 (0.84,1.25)

0.83

P for trend

  

0.002

 

< 0.001

 

< 0.001

 

Magnesium

< 5th

0.50–1.39

166 (22.55)

1.76 (1.48,2.11)

< 0.001

1.85 (1.54,2.21)

< 0.001

1.43 (1.19,1.72)

< 0.001

5 to < 20th

1.40–1.49

420 (19.02)

1.25 (1.09,1.43)

0.17

1.36 (1.19,1.55)

< 0.001

1.22 (1.06,1.39)

0.004

20 to < 40th

1.50–1.59

492 (16.71)

1.01 (0.89,1.14)

0.93

1.01 (0.89,1.14)

0.90

0.98 (0.87,1.12)

0.80

40 to < 60th

1.60–1.69

500 (16.98)

1.00 (Reference)

–

1.00 (Reference)

–

1.00 (Reference)

–

60 to < 80th

1.70–1.79

495 (16.81)

1.00 (0.88,1.13)

0.96

0.94 (0.83,1.06)

0.31

0.97 (0.85,1.10)

0.59

80 to < 95th

1.80–1.89

338 (15.31)

0.88 (0.77,1.02)

0.09

0.84 (0.73,0.96)

0.01

0.89 (0.78,1.03)

0.11

≥ 95th

1.90–3.10

128 (17.39)

1.01 (0.83,1.23)

0.90

0.95 (0.78,1.16)

0.64

0.97 (0.80,1.19)

0.78

P for trend

  

< 0.001

 

< 0.001

 

< 0.001

 

Phosphate

< 5th

1.00-2.59

153 (20.79)

1.26 (1.05,1.52)

0.01

1.07 (0.89,1.29)

0.48

1.00 (0.83,1.21)

0.97

5 to < 20th

2.60–2.99

397 (17.98)

1.10 (0.96,1.26)

0.16

1.01 (0.88,1.16)

0.92

0.98 (0.85,1.12)

0.73

20 to < 40th

3.00-3.29

491 (16.68)

1.02 (0.90,1.16)

0.79

0.99 (0.87,1.13)

0.89

0.99 (0.87,1.12)

0.83

40 to < 60th

3.30–3.49

478 (16.23)

1.00 (Reference)

–

1.00 (Reference)

–

1.00 (Reference)

–

60 to < 80th

3.50–3.79

513 (17.43)

1.07 (0.94,1.21)

0.32

1.13 (0.99,1.28)

0.06

1.12 (0.99,1.27)

0.08

80 to < 95th

3.80–4.19

383 (17.35)

1.09 (0.95,1.25)

0.23

1.20 (1.05,1.38)

0.01

1.18 (1.03,1.36)

0.02

≥ 95th

4.20–9.10

124 (16.85)

1.14 (0.93,1.39)

0.20

1.33 (1.09,1.63)

0.01

1.32 (1.07,1.62)

0.01

P for trend

  

< 0.001

 

< 0.001

 

< 0.001

 

Calcium

< 5th

7.28–9.23

122 (16.58)

0.86 (0.71,1.06)

0.15

0.87 (0.71,1.07)

0.18

0.90 (0.74,1.11)

0.33

5 to < 20th

9.24–9.53

364 (16.49)

0.89 (0.77,1.02)

0.08

0.90 (0.79,1.03)

0.13

0.91 (0.79,1.04)

0.16

20 to < 40th

9.54–9.77

497 (16.88)

0.94 (0.83,1.06)

0.33

0.97 (0.86,1.10)

0.68

0.97 (0.86,1.10)

0.67

40 to < 60th

9.78–9.97

512 (17.39)

1.00 (Reference)

–

1.00 (Reference)

–

1.00 (Reference)

–

60 to < 80th

9.98–10.21

540 (18.34)

1.09 (0.96,1.23)

0.19

1.10 (0.97,1.24)

0.13

1.07 (0.95,1.22)

0.25

80 to < 95th

10.22–10.57

376 (17.03)

1.05 (0.91,1.20)

0.51

1.10 (0.96,1.26)

0.18

1.03 (0.90,1.18)

0.65

≥ 95th

10.58–13.56

128 (17.39)

1.17 (0.96,1.43)

0.12

1.20 (0.98,1.47)

0.07

1.08 (0.88,1.32)

0.45

P for trend

  

0.02

 

0.02

 

0.50

 
  1. aAdjusted by age, gender and race
  2. bAdjusted by model 1 + hypertension, diabetes mellitus, smoke, drink, body mass index, left ventricular hypertrophy at ECG, antiarrhythmic drugs, plasma creatinine, metabolic equivalent, low-density lipoprotein cholesterol, C-reactive protein and angiotensin-converting enzyme inhibitors