Table 3 Causal associations between genetically determined serum electrolytes and the risk of AF in Mendelian Randomization analyses

Potassium-AF

Inverse variance weighted

15

0.999

0.867

1.151

0.987

Weighted median

15

1.006

0.823

1.230

0.952

Weighted mode

15

1.103

0.778

1.562

0.591

MR Egger

15

1.199

0.841

1.708

0.333

Test for Heterogeneity: P = 0.781 (MR-Egger) and P = 0.754 (IVW)

Test for Horizontal pleiotropy: MR-Egger intercept = -0.0073, se = 0.00660, P = 0.290

Magnesium-AF

Inverse variance weighted

19

1.044

0.915

1.190

0.522

Weighted median

19

1.035

0.858

1.247

0.721

Weighted mode

19

1.017

0.747

1.384

0.916

MR Egger

19

1.100

0.857

1.413

0.465

Test for Heterogeneity: P = 0.309 (MR-Egger) and P = 0.355 (IVW)

Test for Horizontal pleiotropy: MR-Egger intercept = -0.0026, se = 0.00536, P = 0.632

Phosphate-AF

Inverse variance weighted

143

0.728

0.471

1.125

0.153

Weighted median

143

0.747

0.449

1.244

0.262

Weighted mode

143

0.733

0.464

1.157

0.184

MR Egger

143

0.617

0.295

1.289

0.201

Test for Heterogeneity: P = 1.751E-18 (MR-Egger) and P = 2.211E-18 (IVW)

Test for Horizontal pleiotropy: MR-Egger intercept = 0.0010, se = 0.00189, P = 0.586

Calcium-AF

Inverse variance weighted

20

0.979

0.859

1.115

0.747

Weighted median

20

1.025

0.865

1.216

0.772

Weighted mode

20

1.085

0.792

1.487

0.618

MR Egger

20

0.915

0.577

1.451

0.710

Test for Heterogeneity: P = 0.186 (MR-Egger) and P = 0.227 (IVW)

Test for Horizontal pleiotropy: MR-Egger intercept = 0.0024, se = 0.00804, P = 0.768