Table 3 Significantly enriched Gene Ontologies (GOs) assigned to genes differentially expressed between 2nd instar Leguminivora glycinivorella larvae fed on Cry1Ac compared to non-Bt Glycine max among cellular component (CC), biological process (BP) and molecular function (MF) categories at GO level 2. False discovery rate (FDR) thresholds of 1.0^–4 applied CC and MF categories, and ≤ 1.0^–6 to category terms

CC

GO:0044437

vacuolar part

2

7.90

9.79E-07

CC

GO:0042579

microbody

2

7.76

1.74E-06

MF

GO:0004312

fatty acid synthase activity

2

12.8

1.71E-09

MF

GO:0016903

oxidoreductase activity, acting on the aldehyde or oxo group of donors

2

9.77

2.26E-07

MF

GO:0005342

organic acid transmembrane transporter activity

2

8.40

1.41E-06

MF

GO:0008509

anion transmembrane transporter activity

2

6.40

3.32E-05

MF

GO:0050662

coenzyme binding

2

6.17

3.69E-05

MF

GO:0005319

lipid transporter activity

2

6.83

8.45E-05

MF

GO:0005506

iron ion binding

2

6.42

1.37E-04

MF

GO:0046906

tetrapyrrole binding

2

6.18

1.89E-04

MF

GO:0015238

drug transmembrane transporter activity

2

5.98

3.50E-04

MF

GO:0003924

GTPase activity

2

5.72

5.11E-04

MF

GO:0016247

channel regulator activity

2

5.48

6.50E-04

MF

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2

4.97

9.35E-04

BP

GO:0019748

secondary metabolic process

2

18.43

2.12E-21

BP

GO:1,901,615

organic hydroxy compound metabolic process

2

11.68

7.11E-13

BP

GO:0032787

monocarboxylic acid metabolic process

2

10.68

1.24E-11

BP

GO:0008610

lipid biosynthetic process

2

10.24

3.95E-11

BP

GO:0009410

response to xenobiotic stimulus

2

10.85

6.30E-09

BP

GO:0033993

response to lipid

2

9.00

1.22E-08

BP

GO:0010817

regulation of hormone levels

2

8.76

4.53E-08

BP

GO:0032870

cellular response to hormone stimulus

2

8.66

5.51E-08

BP

GO:0055114

oxidation–reduction process

2

7.91

8.37E-08

BP

GO:0015849

organic acid transport

2

9.20

1.01E-07

BP

GO:0021700

developmental maturation

2

9.03

1.40E-07

BP

GO:0006820

anion transport

2

8.29

1.62E-07

BP

GO:0001101

response to acid chemical

2

8.33

2.12E-07

BP

GO:0062012

regulation of small molecule metabolic process

2

8.17

4.16E-07

BP

GO:0017144

drug metabolic process

2

6.93

6.27E-07

BP

GO:0016319

mushroom body development

2

10.59

9.11E-07

BP

GO:1,901,701

cellular response to oxygen-containing compound

2

6.97

1.28E-06

BP

GO:0019216

regulation of lipid metabolic process

2

7.54

2.14E-06

BP

GO:0046394

carboxylic acid biosynthetic process

2

6.67

2.71E-06

BP

GO:1,905,952

regulation of lipid localization

2

8.20

4.27E-06

BP

GO:0016198

axon choice point recognition

2

9.64

7.12E-06

BP

GO:0006790

sulfur compound metabolic process

2

6.60

8.01E-06