Fig. 4

Integration of P65 hippocampal RNA-seq, ATAC-seq, and ChIP-H3K9me3-seq data. A FID and IS comparison showing 159 of 731 (22%) loci with specific changes in chromatin accessibility. These changes indicate activated synaptic transmission and neuronal cell death accompanied by inhibited branching of neurites, migration of neural cells, and emotional behavior. B FIDch vs IS comparison showing 88 loci with specific H3K9me3 changes, which indicate an activated neuronal development. 197 loci with specific changes in chromatin accessibility indicate activated cellular function, including cellular homeostasis, cell movement, cell death, and quantity of neuroglia, but inhibited nerve degeneration. C ISch and IS comparison showing 107 loci with both ATAC and H3K9me3 changes, which indicate activated synaptic transmission and quantity of cells. 155 loci with specific H3K9me3 changes indicate reduced neuronal viability but activated development of neurons, neurotransmission, and cell migration. 210 loci with specific changes in chromatin accessibility indicate both inhibited degeneration and activated apoptosis of neurons via different set of genes, as well as activated development of the nervous system