Fig. 5

Alignments of ATAC-seq and H3K9me3-seq peaks among treatment groups. A Overlapping ATAC and H3K9me3 peaks among IS, FID, and FIDch groups localized to the intergenic regions of 91 nearby genes, which mapped onto a gene network centering on the Brain-derived neurotrophic factor (BDNF), Presenilin-1 (PSEN1), and Amyloid precursor protein (APP), and methylcytosine-binding protein 2 (MeCP2). B Overlapping ATAC and H3K9me3 peaks between IS and ISch groups showed 142 choline-specific effect genes that mapped onto a gene network centering on alpha-synuclein (SNCA), Huntingtin (HTT), transcription factor 7 like 2 (TCF7L2), and interferon gamma (INFG)