Fig. 1

Changes of cardiac function and structure in db/db mice. (A) Echocardiographic images showed that the impairment of cardiac systolic and diastolic function in db/db mice compared to C57 mice. (B) cardiac parameters hinted a decrease in both systolic and diastolic function in the hearts of db/db mice compared to C57 mice. (C) H&E staining images showed disorganized myocardial arrangement in db/db mice. Masson staining images revealed that cardiac collagen fibra were remarkably increased in db/db mice. TUNEL staining indicated that db/db mice have more myocardial apoptosis than C57 mice. Scale bar = 50 μm. Original magnification: 1:400. n = 6. Means ± SD were presented. **P < 0.01, *P < 0.05 versus C57 mice