Fig. 8

KEGG pathway analyses. A The 493 genes in the TF network were clustered using KEGG pathway analysis. KEGG pathway nodes are indicated by number; 1 = MAPK signaling pathway – fly, 2 = Apoptosis, 3 = Longevity regulating pathway, 4 = MAPK signaling pathway, 5 = PI3K-Akt signaling pathway, 6 = Cellular senescence, 7 = Hippo signaling pathway – fly, 8 = Signaling pathways regulating pluripotency of stem cells, 9 = Hippo signaling pathway, 10 = TGF-beta signaling pathway. B KEGG pathway analysis of the 57 TF genes that are expressed at significantly higher levels in Kc cells than S2 cells (Kc up). KEGG pathway nodes are indicated by number; 1 = Circadian rhythm, 2 = TGF-beta signaling pathway, 3 = Hippo signaling pathway – fly, 4 = Signaling pathways regulating pluripotency of stem cells, 5 = Thyroid hormone signaling pathway, 6 = Cellular senescence, 7 = PI3K-Akt signaling pathway, 8 = Mitophagy, 9 = Longevity regulating pathway, 10 = FoxO signaling pathway. C KEGG pathway analysis of the 66 genes that are expressed at significantly higher levels in S2 cells than Kc cells (Kc down). KEGG pathway nodes are indicated by number; 1 = Hippo signaling pathway, 2 = TGF-beta signaling pathway, 3 = Hippo signaling pathway – fly, 4 = MAPK signaling pathway – fly, 5 = Apoptosis, 6 = Toll and lmd signaling pathway, 7 = Ras signaling pathway, 8 = Sphingolipid signaling pathway, 9 = Cellular senescence, 10 = Thyroid hormone signaling pathway. Squares indicate defined KEGG pathways (nodes) and circles indicate individual TF coding genes. The KEGG pathway nodes are color ranked by the number of genes connected in the pathway, with only the top 10 pathways with the largest number of genes displayed in each panel. The different line colors connecting nodes to genes represent KEGG classification of the pathway; cellular processes (red), environmental information processing (blue) or organic systems (yellow)