Table 1 Univariate analysis and multivariate analysis cox regression in TCGA GC cohort

Age

367

1.022 (1.005–1.039)

0.009

1.037 (1.017–1.057)

< 0.001

Histologic grade

361

G1

10

Reference

G2

134

1.648 (0.400–6.787)

0.489

G3

217

2.174 (0.535–8.832)

0.278

Gender

370

Female

133

Reference

Male

237

1.267 (0.891–1.804)

0.188

Stage I

50

Reference

Reference

Stage II

110

1.551 (0.782–3.078)

0.209

1.529 (0.516–4.528)

0.443

Stage III

149

2.381 (1.256–4.515)

0.008

1.487 (0.360–6.139)

0.583

Stage IV

38

3.991 (1.944–8.192)

< 0.001

3.317 (0.764–14.410)

0.110

Pathologic T stage

362

T1

18

Reference

Reference

T2

78

6.725 (0.913–49.524)

0.061

3.606 (0.451–28.806)

0.226

T3

167

9.548 (1.326–68.748)

0.025

4.013 (0.449–35.894)

0.214

T4

99

9.634 (1.323–70.151)

0.025

3.851 (0.417–35.570)

0.235

Pathologic N stage

352

N0

107

Reference

Reference

N1

97

1.629 (1.001–2.649)

0.049

1.220 (0.600–2.480)

0.583

N2

74

1.655 (0.979–2.797)

0.060

1.447 (0.607–3.449)

0.404

N3

74

2.709 (1.669–4.396)

< 0.001

1.847 (0.779–4.376)

0.163

Pathologic M stage

352

M0

327

Reference

Reference

M1

25

2.254 (1.295–3.924)

0.004

1.255 (0.537–2.936)

0.600

GLA

370

0.799 (0.615–1.039)

0.094

0.786 (0.556–1.109)

0.170

LAMC1

370

1.226 (1.047–1.435)

0.011

1.296 (1.089–1.543)

0.004

TRAF2

370

0.768 (0.590–0.999)

0.049

0.771 (0.541–1.098)

0.150