Volume 12 Supplement 5

The 2010 International Conference on Bioinformatics and Computational Biology (BIOCOMP 2010): Genomics

Research

Edited by Ke Zhang, Mehdi Pirooznia, Hamid R Arabnia

BIOCOMP 2010. The 2010 International Conference on Bioinformatics and Computational Biology.

Las Vegas, NV, USA

12-15 July 2010

  1. Introduction

    Genomic signatures and gene networking: challenges and promises

    This is an editorial report of the supplement to BMC Genomics that includes 15 papers selected from the BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology as well as other...

    Ke Zhang, Mehdi Pirooznia, Hamid R Arabnia, Jack Y Yang, Liangjiang Wang, Zuojie Luo and Youping Deng

    BMC Genomics 2011 12(Suppl 5):I1

    Published on: 23 December 2011

  2. Research article

    Gene selection and classification for cancer microarray data based on machine learning and similarity measures

    Microarray data have a high dimension of variables and a small sample size. In microarray data analyses, two important issues are how to choose genes, which provide reliable and good prediction for disease sta...

    Qingzhong Liu, Andrew H Sung, Zhongxue Chen, Jianzhong Liu, Lei Chen, Mengyu Qiao, Zhaohui Wang, Xudong Huang and Youping Deng

    BMC Genomics 2011 12(Suppl 5):S1

    Published on: 23 December 2011

  3. Research article

    Changes in predicted protein disorder tendency may contribute to disease risk

    Recent studies suggest that many proteins or regions of proteins lack 3D structure. Defined as intrinsically disordered proteins, these proteins/peptides are functionally important. Recent advances in next gen...

    Yang Hu, Yunlong Liu, Jeesun Jung, A Keith Dunker and Yadong Wang

    BMC Genomics 2011 12(Suppl 5):S2

    Published on: 23 December 2011

  4. Research article

    Maximum predictive power of the microarray-based models for clinical outcomes is limited by correlation between endpoint and gene expression profile

    Microarray data have been used for gene signature selection to predict clinical outcomes. Many studies have attempted to identify factors that affect models' performance with only little success. Fine-tuning o...

    Chen Zhao, Leming Shi, Weida Tong, John D Shaughnessy, André Oberthuer, Lajos Pusztai, Youping Deng, W Fraser Symmans and Tieliu Shi

    BMC Genomics 2011 12(Suppl 5):S3

    Published on: 23 December 2011

  5. Research article

    Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers

    Panax notoginseng (Burk) F.H. Chen is important medicinal plant of the Araliacease family. Triterpene saponins are the bioactive constituents in P. notoginseng. However, available genomic information regarding th...

    Hongmei Luo, Chao Sun, Yongzhen Sun, Qiong Wu, Ying Li, Jingyuan Song, Yunyun Niu, Xianglin Cheng, Hongxi Xu, Chuyuan Li, Juyan Liu, André Steinmetz and Shilin Chen

    BMC Genomics 2011 12(Suppl 5):S5

    Published on: 23 December 2011

  6. Research article

    Maximizing biomarker discovery by minimizing gene signatures

    The use of gene signatures can potentially be of considerable value in the field of clinical diagnosis. However, gene signatures defined with different methods can be quite various even when applied the same d...

    Chang Chang, Junwei Wang, Chen Zhao, Jennifer Fostel, Weida Tong, Pierre R Bushel, Youping Deng, Lajos Pusztai, W Fraser Symmans and Tieliu Shi

    BMC Genomics 2011 12(Suppl 5):S6

    Published on: 23 December 2011

  7. Research article

    A gene selection method for GeneChip array data with small sample sizes

    In microarray experiments with small sample sizes, it is a challenge to estimate p-values accurately and decide cutoff p-values for gene selection appropriately. Although permutation-based methods have proved ...

    Zhongxue Chen, Qingzhong Liu, Monnie McGee, Megan Kong, Xudong Huang, Youping Deng and Richard H Scheuermann

    BMC Genomics 2011 12(Suppl 5):S7

    Published on: 23 December 2011

  8. Research article

    Predicting adverse side effects of drugs

    Studies of toxicity and unintended side effects can lead to improved drug safety and efficacy. One promising form of study comes from molecular systems biology in the form of "systems pharmacology". Systems ph...

    Liang-Chin Huang, Xiaogang Wu and Jake Y Chen

    BMC Genomics 2011 12(Suppl 5):S11

    Published on: 23 December 2011

  9. Research article

    Transcriptomic profiles of peripheral white blood cells in type II diabetes and racial differences in expression profiles

    Along with obesity, physical inactivity, and family history of metabolic disorders, African American ethnicity is a risk factor for type 2 diabetes (T2D) in the United States. However, little is known about th...

    Jinghe Mao, Junmei Ai, Xinchun Zhou, Ming Shenwu, Manuel Ong, Marketta Blue, Jasmine T Washington, Xiaonan Wang and Youping Deng

    BMC Genomics 2011 12(Suppl 5):S12

    Published on: 23 December 2011

Portable peer review

 The editors of BMC Genomics support initiatives that expedite the peer review process and are happy to consider manuscripts that have been reviewed in Axios Review or Peerage of Science. Please indicate in your cover letter if this applies to your manuscript.

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