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Table 1 List of differentially expressed genes between L. amazonensis-harbouring MΦ and parasite-free MΦ.

From: Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes

Symbol

Name

Probe-set

LocusLink

Affymetrix (RTqPCR)

P-value

abcD2

ATP-binding cassette, sub-family D (ALD), member 2

1438431_ata

26874

-2.11

4.40e-03

acaca

acetyl-Coenzyme A carboxylase alpha

1427595_at

107476

-1.32

4.79e-03

acsl3

acyl-CoA synthetase long-chain family member 3

1452771_s_at

74205

+2.09

1.48e-03

adhfe1

alcohol dehydrogenase, iron containing, 1

1424393_s_at

76187

+1.61

4.40e-02

akr1a1

aldo-keto reductase family 1, member A1 (aldehyde reductase)

1430123_a_at

58810

+1.13

1.22e-03

aldoA

aldolase 1, A isoform

1433604_x_ata

11674

+1.72

1.28e-02

aldoC

aldolase 3, C isoform

1451461_a_at

11676

+1.89

1.13e-02

anxA1

annexin A1

1444016_ata

16952

+2.68

4.47e-05

apoc2

apolipoprotein C-II

1418069_at

11813

-1.63

4.57e-02

arg2

Arginase 2

1418847_at

11847

NM (+1.91)

NS

atf1

activating transcription factor 1

1417296_at

11908

+1.84

4.20e-03

atf3

activating transcription factor 3

1449363_at

11910

+1.77

1.09e-02

atp6V0a1

ATPase, H+ transporting, lysosomal V0 subunit a isoform 1

1460650_ata

11975

+1.82

8.31e-03

atp6V0c

ATPase, H+ transporting, V0 subunit C

1435732_x_at

11984

+1.27

5.48e-13

atp6V0d2

ATPase, H+ transporting, V0 subunit D, isoform 2

1444176_ata

24234

+2.32

1.12e-05

atp6V1a

ATPase, H+ transporting, V1 subunit A1

1422508_at

11964

+1.57

3.96e-02

atp6V1c1

ATPase, H+ transporting, V1 subunit C, isoform 1

1419546_ata

66335

+2.31

1.10e-05

atp6V1d

ATPase, H+ transporting, V1 subunit D

1416952_ata

73834

+1.82

6.97e-03

atp6V1g1

ATPase, H+ transporting, V1 subunit G isoform 1

1423255_ata

66290

+1.84

3.78e-03

atp6V1h

ATPase, H+ transporting, lysosomal, V1 subunit H

1415826_at

108664

+1.69

2.39e-02

azin1

antizyme inhibitor 1

1422702_at

54375

+1.96

1.46e-03

brd8

bromodomain containing 8

1427193_at

78656

+1.08

3.75e-02

c1qa

complement component 1, q subcomponent, alpha polypeptide

1417381_at

12259

-1.48

3.15e-02

c1qb

complement component 1, q subcomponent, beta polypeptide

1417063_at

12260

-1.77

3.31e-04

c3

complement component 3

1423954_at

12266

-2.37

7.05e-06

c4b

complement component 4 (within H-2S)

1418021_at

12268

-1.76

4.55e-02

c5ar1

complement component 5a receptor 1

1439902_at

247623

-1.63

4.62e-02

ccr2

chemokine (C-C motif) receptor 2

1421187_ata

12772

-1.83 (-2.35)

6.42e-03

ccr3

chemokine (C-C motif) receptor 3

1422957_at

12771

-2.58 (-3.88)

2.49e-05

cd14

CD14 antigen

1417268_at

12475

-1.73

1.54e-03

cd200

CD200 antigen

1448788_at

17470

+4.14 (+6.52)

5.48e-13

cd274

CD274 antigen

1419714_at

60533

+1.93

1.61e-03

cd86

CD86 antigen

1420404_ata

12524

-1.83 (-1.03)

1.44e-02

cfh

complement component factor h

1450876_at

12628

-2.80

6.08e-06

c-fos

FBJ osteosarcoma oncogene

1423100_at

14281

-1.93

3.30e-03

ch25h

cholesterol 25-hydroxylase

1449227_at

12642

-6.57

1.39e-22

cmklr1

chemokine-like receptor 1

1456887_at

14747

-2.20

1.57e-04

cx3cr1

chemokine (C-X3-C) receptor 1

1450020_at

13051

-2.65 (-5.26)

2.39e-05

cyp51

cytochrome P450, family 51

1450646_ata

13121

+2.78

2.10e-07

dhcr24

24-dehydrocholesterol reductase

1451895_a_at

74754

+3.17

2.69e-09

dio2

deiodinase, iodothyronine, type II

1418937_ata

13371

+25.92 (+41.03)

0.00e+00

eno2

enolase 2, gamma neuronal

1418829_a_at

13807

+2.60

6.08e-06

fabp3

fatty acid binding protein 3

1416023_at

14077

+2.29

5.58e-05

fabp4

fatty acid binding protein 4

1417023_a_ata

11770

+6.42

0.00e+00

fabp5

fatty acid binding protein 5

1416022_ata

16592

+1.57

4.70e-08

fbp1

fructose bisphosphatase 1

1448470_at

14121

-2.16

4.68e-03

fdft1

farnesyl diphosphate farnesyl transferase 1

1438322_x_ata

14137

+2.62

4.00e-06

fdps

farnesyl diphosphate synthetase

1423418_at

110196

+3.59

9.78e-12

h-2ma

histocompatibility 2, class II, locus DMa

1422527_at

14998

-1.88

3.00e-03

h60

histocompatibility 60

1439343_at

15101

-2.07

5.30e-09

hk2

hexokinase 2

1422612_at

15277

+1.75

1.09e-02

hk3

hexokinase 3

1435490_at

212032

+2.03

3.72e-04

hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

1427229_at

15357

+1.95

2.34e-03

hmgcs1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

1433446_at

208715

+2.48

1.07e-06

hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

1457248_x_at

15490

+2.73

1.41e-05

icam1

intercellular adhesion molecule

1424067_at

15894

-1.75

1.43e-02

icam2

intercellular adhesion molecule 2

1448862_at

15896

-1.85

2.88e-02

idi1

isopentenyl-diphosphate delta isomerase

1451122_ata

319554

+2.72

2.77e-07

ifngr1

interferon gamma receptor 1

1448167_at

15979

-1.83 (-2.16)

4.66e-03

il10

interleukin 10

1450330_at

16153

-2.97 (-4.46)

1.11e-07

il10ra

interleukin 10 receptor, alpha

1448731_at

16154

-2.16 (-2.56)

4.40e-04

il11ra1

interleukin 11 receptor, alpha chain 1

1417505_s_at

16157

+2.24 (+3.55)

9.89e-05

il17rb

interleukin 17 receptor B

1420678_a_at

50905

-1.41

2.93e-02

il18

interleukin 18

1417932_at

16173

-1.77 (-2.12)

1.06e-02

il1b

interleukin 1 beta

1449399_a_at

16176

-3.09 (-5.17)

3.49e-07

il1rn

interleukin 1 receptor antagonist

1423017_a_ata

16181

+4.19 (+7.86)

0.00e+00

insig1

insulin induced gene 1

1454671_at

231070

+2.62

9.17e-08

itga4

integrin alpha 4

1456498_ata

16401

-2.06

2.37e-03

itgal

integrin alpha L

1435560_at

16408

-2.00

7.72e-03

klrk1

killer cell lectin-like receptor subfamily K, member 1

1450495_a_at

27007

-1.72

2.21e-02

ldhA

lactate dehydrogenase 1, A chain

1419737_a_at

16828

+1.79

2.71e-04

ldlr

low density lipoprotein receptor

1450383_ata

16835

+4.68

1.49e-13

lipe

lipase, hormone sensitive

1422820_at

16890

-2.20

2.90e-03

lpl

lipoprotein lipase

1431056_a_at

16956

-1.44

3.24e-02

lss

lanosterol synthase

1420013_s_at

16987

+2.05

2.29e-03

maoa

monoamine oxidase A

1428667_ata

17161

+2.56

4.71e-06

mapk14

mitogen activated protein kinase 14 (p38 mapk)

1416703_at

26416

-1.61

4.97e-02

mgll

monoglyceride lipase

1426785_s_at

23945

+3.40

3.75e-08

mvd

mevalonate (diphospho) decarboxylase

1417303_ata

192156

+2.15

6.33e-04

ncoa4

nuclear receptor coactivator 4

1450006_at

27057

+1.65

3.15e-02

nfkbia

nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha

1448306_at

18035

-1.83

5.53e-03

nos2

nitric oxide synthase 2, inducible, macrophage

1420393_at

18126

NM (+1.28)

NS

odc1

Ornithine decarboxylase 1

1427364_a_at

18263

NM (+1.18)

NS

p4ha2

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α II polypeptide

1417149_at

18452

+2.27

1.96e-03

pfkl

phosphofructokinase, liver, B-type

1439148_a_at

18641

+1.68

2.32e-02

pkg1

phosphoglycerate kinase 1

1417864_at

18655

+1.70

8.88e-03

pkm2

pyruvate kinase, muscle

1417308_at

18746

+1.51

4.57e-02

ppap2B

phosphatidic acid phosphatase type 2B

1448908_ata

67916

+8.53

0.00e+00

pros1

protein S (alpha)

1426246_at

19128

-2.09

2.66e-03

relb

avian reticuloendotheliosis viral (v-rel) oncogene related B

1417856_at

19698

-1.91

1.94e-02

sat1

spermidine/spermine N1-acetyl transferase 1

1420502_at

20229

+1.47

2.30e-02

sc4mol

sterol-C4-methyl oxidase-like

1423078_a_at

66234

+2.28

1.61e-05

sc5d

sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

1451457_ata

235293

+2.57

2.37e-06

scd1

stearoyl-Coenzyme A desaturase 1

1415964_ata

20249

+2.68

4.50e-05

scd2

stearoyl-Coenzyme A desaturase 2

1415824_ata

20250

+2.45

1.32e-06

serping1

serine (or cysteine) peptidase inhibitor, clade G, member 1

1416625_at

12258

-1.35

4.84e-05

slc7a2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

1436555_ata

11988

+4.14

6.07e-12

sms

spermine synthase

1434190_ata

20603

NM [-1.38b]

NS

socs6

suppressor of cytokine signaling 6

1450129_a_at

54607

+1.84

4.18e-03

sqle

squalene epoxidase

1415993_at

20775

+4.30

0.00e+00

srebf2

sterol regulatory element binding factor 2

1426744_at

20788

+1.84

1.26e-02

srm

spermidine synthase

1421260_a_at

20810

NM [-1.22b]

NS

stard4

StAR-related lipid transfer (START) domain containing 4

1429239_a_ata

170459

+2.31

2.43e-04

tlr2

toll-like receptor 2

1419132_at

24088

-3.11 (-1.58)

1.83e-08

tlr7

toll-like receptor 7

1449640_at

170743

-1.77 (-1.07)

4.61e-02

tlr8

toll-like receptor 8

1450267_at

170744

-1.79

1.00e-02

tollip

toll interacting protein

1423048_a_at

54473

+1.69

3.57e-02

  1. This table is an excerpt from the table of the 1,248 significantly modulated probe-sets, available as online Additional file 1, and contains some genes tested by RTQPCR.
  2. a when several probe-sets detect a target gene, data are only shown for the most modulated one. NM: No Modulation significantly detected with Affymetrix technology. NS: Not Significant p-value. b mean values obtained from the raw fluorescence intensities.