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Table 4 List of genes differentially expressed at P0, P3, P7 and P10 in the cerebellum of Ts1Cje mice as compared to euploids.

From: Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

Symbol

P0

P3

P7

P10

Name

Gene Ontology

1700021N20Rik

0.79

1.43

0.71

0.75

RIKEN cDNA 1700021N20

 

Atp5o

1.27

1.26

1.59

1.46

ATP synthase, H+ trans- porting, mitochondrial F1 complex, O subunit

hydrogen-transporting ATP synthase activity; mitochondrion; catalytic core F(1); ion transport; metal ion binding

Bpil3

1.19

1.24

1.25

1.23

bactericidal/permeability- increasing protein-like 3

lipid binding

Dnahc11

2.42

2.63

3.94

3.02

dynein, axonemal, heavy chain 11

axonemal dynein complex; cilium;determination of left/right symmetry; microtubule motor activity

Hspy2l

1.40

1.29

1.44

1.46

 

protein folding; DNA bind ing;transcription; nucleus

Ifngr2

1.26

1.51

1.28

1.47

interferon gamma receptor 2

receptor activity

Girk2

1.21

1.40

1.31

1.30

potassium inwardly- rectifying channel, sub- family J, member 6

G-protein activated inward rectifier potassium channel activity; integral to plasma membrane; potassium ion transport; voltage-gated ion channel activity

March1

1.40

1.23

1.36

1.37

membrane-associated ring finger (C3HC4) 1

ubiquitin cycle; zinc ion binding

Pcp4

1.50

1.41

1.70

1.53

Purkinje cell protein 4

calcium ion binding

Phtf1

1.60

1.26

1.40

1.37

putative homeodomain transcription factor 1

DNA binding, transcription factor activity; nucleus

Sod1

1.56

1.43

1.89

1.64

superoxide dismutase 1, soluble

removal of superoxide radicals;response to oxidative stress; copper, zinc superoxide dismutase activity;mitochondrion; DNA fragmentation during apoptosis; activation of MAPK activity

Son

1.32

1.48

1.60

1.53

Son cell proliferation pro tein

protein binding; intracellular; DNA binding;double-stranded RNA binding; nucleus

V1ri10

1.37

1.30

1.56

1.46

vomeronasal 1 receptor, I10

pheromone receptor activity; integral to plasma membrane

  1. All ratios have a p-value < 0.05 (ANOVA). In bold are three-copy genes.
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BMC Genomics

ISSN: 1471-2164

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