Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

BMC Genomics

Table 7 Additional list of three-copy genes that are over-expressed in the external granule cell layer of Ts1Cje as compared to euploid at P0 (q > 0.05)

SYMBOL	Ratio	p-value	q-value	Chr	GO biological process category
Girk2	1.58	0,000	0,109	16	potassium ion transport
Son	1.48	0,001	0,206	16
Cryzl1	1.4	0,000	0,084	16	zinc ion binding
Gart	1.37	0,000	0,080	16	purine nucleotide biosynthetic process
Olig1	1.37	0,048	0,996	16	neuron fate commitment
Donson	1.34	0,000	0,109	16	multicellular organismal development
Dscr3	1.33	0,001	0,238	16	vacuolar transport
Olig2	1.3	0,002	0,343	16	neuron fate commitment
Hmgn1	1.28	0,000	0,109	16	establishment and/or maintenance of chromatin architecture
Cbr3	1.25	0,030	0,996	16	metabolic process
Prdm15	1.23	0,002	0,331	16
Ifnar2	1.16	0,019	0,996	16	cell proliferation

Twelve three-copy genes were found significantly differentially expressed by Student t-test (p < 0.05) but failed the False Discovery Rate controlling procedure of Benjamini and Hochberg (q > 0.05).

ISSN: 1471-2164