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Table 7 Functional classification of human genes with alternative 5'UTRs

From: Evolution of alternative and constitutive regions of mammalian 5'UTRs

GO keyword ALT ALL P
response to stimulus 20 597 4.2E-92
G-protein coupled receptor protein signaling pathway 52 842 1.8E-64
signal transduction 232 1778 1.2E-20
receptor activity 189 1425 1.3E-15
RNA binding 66 559 7.5E-11
membrane 754 4608 1.8E-09
translation 26 261 4.5E-09
protein folding 24 243 1E-08
extracellular space 59 480 2.7E-08
rhodopsin-like receptor activity 28 267 3.6E-08
extracellular region 92 686 7.3E-08
biological process 83 627 9.8E-08
nucleus 669 4043 2.1E-07
integral to membrane 571 3467 6.4E-07
DNA binding 195 1285 1.5E-06
nucleic acid binding 93 669 1.7E-06
proteinaceous extracellular matrix 23 210 5.1E-06
intracellular 303 1896 7.2E-06
RNA splicing 22 201 7.9E-06
regulation of apoptosis 33 101 2.1E-05
  1. Human genes are partitioned into two groups: genes with alternative 5'UTRs (ALT) and ALL genes. Gene Ontology keyword descriptions are listed in left column. Keyword frequencies were tabulated for the ALT and ALL sets, and normalized by the total numbers in each set. P-values were calculated using the χ2 test.