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Table 7 Functional classification of human genes with alternative 5'UTRs

From: Evolution of alternative and constitutive regions of mammalian 5'UTRs

GO keyword

ALT

ALL

P

response to stimulus

20

597

4.2E-92

G-protein coupled receptor protein signaling pathway

52

842

1.8E-64

signal transduction

232

1778

1.2E-20

receptor activity

189

1425

1.3E-15

RNA binding

66

559

7.5E-11

membrane

754

4608

1.8E-09

translation

26

261

4.5E-09

protein folding

24

243

1E-08

extracellular space

59

480

2.7E-08

rhodopsin-like receptor activity

28

267

3.6E-08

extracellular region

92

686

7.3E-08

biological process

83

627

9.8E-08

nucleus

669

4043

2.1E-07

integral to membrane

571

3467

6.4E-07

DNA binding

195

1285

1.5E-06

nucleic acid binding

93

669

1.7E-06

proteinaceous extracellular matrix

23

210

5.1E-06

intracellular

303

1896

7.2E-06

RNA splicing

22

201

7.9E-06

regulation of apoptosis

33

101

2.1E-05

  1. Human genes are partitioned into two groups: genes with alternative 5'UTRs (ALT) and ALL genes. Gene Ontology keyword descriptions are listed in left column. Keyword frequencies were tabulated for the ALT and ALL sets, and normalized by the total numbers in each set. P-values were calculated using the χ2 test.