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Table 1 Overrepresented Kegg pathways in macular RPE expressed genes with high, moderate and low expression levels and high or low levels of interindividual variability (coefficient of variation, CV).

From: Functional annotation of the human retinal pigment epithelium transcriptome

   expression level
   all expression levels high (> 90th perc) moderate (50th–90th perc) low (10th–50th perc)
  all CV ecm-receptor interaction (E) oxidative phosphorylation (B,E)
ribosome (B,E)
ATP synthesis (B,E)
phosphatidylinositol signaling system (B,E)
aminosugars metabolism (E)
neuroactive ligand receptor interaction (B,E)
long-term depression (E)
o-glycan biosynthesis (E)
calcium signaling pathway (E)
CV high CV type I diabetes mellitus (B,E)
focal adhesion (B,E)
cytokine-cytokine receptor interaction (E)
complement and coagulation cascades (E)
antigen processing and presentation (E)
ecm-receptor interaction (E)
antigen processing and presentation (B,E)
complement and coagulation cascades (E)
focal adhesion (E)
cytokine-cytokine receptor interaction (E)
type I diabetes mellitus (E)
  low CV - glycosaminoglycan degradation (E) - -
  1. Overrepresented pathways were identified with B: a Benjamini-Hochberg corrected p value < 0.001, or E: an Ease score p value < 0.001. Perc: percentile, high CV: > 90th percentile, low CV: < 10th percentile.