Table 1 Overrepresented Kegg pathways in macular RPE expressed genes with high, moderate and low expression levels and high or low levels of interindividual variability (coefficient of variation, CV).
From: Functional annotation of the human retinal pigment epithelium transcriptome
| Â | Â | expression level | |||
|---|---|---|---|---|---|
|  |  | all expression levels | high (> 90th perc) | moderate (50th–90th perc) | low (10th–50th perc) |
| Â | all CV | ecm-receptor interaction (E) | oxidative phosphorylation (B,E) ribosome (B,E) ATP synthesis (B,E) | phosphatidylinositol signaling system (B,E) aminosugars metabolism (E) | neuroactive ligand receptor interaction (B,E) long-term depression (E) o-glycan biosynthesis (E) calcium signaling pathway (E) |
CV | high CV | type I diabetes mellitus (B,E) focal adhesion (B,E) cytokine-cytokine receptor interaction (E) complement and coagulation cascades (E) antigen processing and presentation (E) ecm-receptor interaction (E) | antigen processing and presentation (B,E) complement and coagulation cascades (E) | focal adhesion (E) cytokine-cytokine receptor interaction (E) | type I diabetes mellitus (E) |
| Â | low CV | - | glycosaminoglycan degradation (E) | - | - |