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Table 3 The top thirty genes with the highest interindividual variation in expression levels (CV) between six healthy human donors, sorted descending by coefficient of variation (CV).

From: Functional annotation of the human retinal pigment epithelium transcriptome

gene symbol Genbank ID mean intensity μint perc CV perc gene name
HSD17B2 NM_002153 95 99 Hydroxysteroid (17-beta) dehydrogenase 2
MYOC NM_000261 99 99 Myocilin, trabecular meshwork inducible glucocorticoid response
OGN NM_014057 92 99 Osteoglycin (osteoinductive factor, mimecan)
SFRP4 NM_003014 93 99 Secreted frizzled-related protein 4
AOC2 NM_009590 91 99 Amine oxidase, copper containing 2 (retina-specific)
DIO3 NM_001362 85 99 Deiodinase, iodothyronine, type III
SLC2A5 NM_003039 62 99 Solute carrier family 2 (facilitated glucose/fructose transporter), member 5
XIST AK025198 99 99 X (inactive)-specific transcript
TFPI2 NM_006528 99 99 Tissue factor pathway inhibitor 2
CYR61 NM_001554 98 99 Cysteine-rich, angiogenic inducer, 61
FGFBP2 NM_031950 84 99 Ksp37 protein
FBP2 NM_003837 64 99 Fructose-1,6-bisphosphatase 2
EGFL6 NM_015507 74 99 EGF-like-domain, multiple 6
IL8 NM_000584 66 99 Interleukin 8
MFAP4 L38486 99 99 Microfibrillar-associated protein 4
CCL2 NM_002982 90 99 Chemokine (C-C motif) ligand 2
ZIC1 NM_003412 67 99 Zinc family member 1 (odd-paired homolog, Drosophila)
COL9A1 NM_001851 88 99 Collagen, type IX, alpha 1
CCL26 NM_006072 79 99 Chemokine (C-C motif) ligand 26
PITX2 NM_000325 89 99 Paired-like homeodomain transcription factor 2
ALDH1A1 NM_000689 78 99 Aldehyde dehydrogenase 1 family, member A1
HBG1 NM_000559 75 99 Hemoglobin, gamma A
S100A6 NM_014624 99 99 S100 calcium binding protein A6
IL6 NM_000600 77 99 Interleukin 6 (interferon, beta 2)
HBG2 NM_000184 71 99 Hemoglobin, gamma G
C13orf33 NM_032849 93 99 Chromosome 13 open reading frame 33
RBM3 NM_006743 96 99 RNA binding motif (RNP1, RRM) protein 3
CFB NM_001710 94 99 Complement factor B
EGR1 NM_001964 99 99 Early growth response 1
PTX3 NM_002852 97 99 Pentraxin-related gene, rapidly induced by IL-1 beta
  1. Note that although XIST, EGFL6 and RBM3 are x-chromosomal transcripts, their high interindividual variation could not be explained by the gender of the donors (data not shown). Perc: percentile.