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Table 3 The top thirty genes with the highest interindividual variation in expression levels (CV) between six healthy human donors, sorted descending by coefficient of variation (CV).

From: Functional annotation of the human retinal pigment epithelium transcriptome

gene symbol

Genbank ID

mean intensity μint perc

CV perc

gene name

HSD17B2

NM_002153

95

99

Hydroxysteroid (17-beta) dehydrogenase 2

MYOC

NM_000261

99

99

Myocilin, trabecular meshwork inducible glucocorticoid response

OGN

NM_014057

92

99

Osteoglycin (osteoinductive factor, mimecan)

SFRP4

NM_003014

93

99

Secreted frizzled-related protein 4

AOC2

NM_009590

91

99

Amine oxidase, copper containing 2 (retina-specific)

DIO3

NM_001362

85

99

Deiodinase, iodothyronine, type III

SLC2A5

NM_003039

62

99

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5

XIST

AK025198

99

99

X (inactive)-specific transcript

TFPI2

NM_006528

99

99

Tissue factor pathway inhibitor 2

CYR61

NM_001554

98

99

Cysteine-rich, angiogenic inducer, 61

FGFBP2

NM_031950

84

99

Ksp37 protein

FBP2

NM_003837

64

99

Fructose-1,6-bisphosphatase 2

EGFL6

NM_015507

74

99

EGF-like-domain, multiple 6

IL8

NM_000584

66

99

Interleukin 8

MFAP4

L38486

99

99

Microfibrillar-associated protein 4

CCL2

NM_002982

90

99

Chemokine (C-C motif) ligand 2

ZIC1

NM_003412

67

99

Zinc family member 1 (odd-paired homolog, Drosophila)

COL9A1

NM_001851

88

99

Collagen, type IX, alpha 1

CCL26

NM_006072

79

99

Chemokine (C-C motif) ligand 26

PITX2

NM_000325

89

99

Paired-like homeodomain transcription factor 2

ALDH1A1

NM_000689

78

99

Aldehyde dehydrogenase 1 family, member A1

HBG1

NM_000559

75

99

Hemoglobin, gamma A

S100A6

NM_014624

99

99

S100 calcium binding protein A6

IL6

NM_000600

77

99

Interleukin 6 (interferon, beta 2)

HBG2

NM_000184

71

99

Hemoglobin, gamma G

C13orf33

NM_032849

93

99

Chromosome 13 open reading frame 33

RBM3

NM_006743

96

99

RNA binding motif (RNP1, RRM) protein 3

CFB

NM_001710

94

99

Complement factor B

EGR1

NM_001964

99

99

Early growth response 1

PTX3

NM_002852

97

99

Pentraxin-related gene, rapidly induced by IL-1 beta

  1. Note that although XIST, EGFL6 and RBM3 are x-chromosomal transcripts, their high interindividual variation could not be explained by the gender of the donors (data not shown). Perc: percentile.