Table 6 Expression levels and interindividual differences of currently known peripheral disease genes with RPE expression[26].
From: Functional annotation of the human retinal pigment epithelium transcriptome
gene symbol | Genbank accession | mean intensity (μint) (percentile) | CV (percentile) | ||
|---|---|---|---|---|---|
high interindividual variation (CV > 90 th percentile) | |||||
COL9A1 | NM_001851 | 5,628 | (88) | 225 | (100) |
RBP4 | NM_006744 | 20,291 | (97) | 196 | (100) |
COL2A1 | NM_001844 | 527 | (37) | 122 | (97) |
GNAT1 | NM_000172 | 100,271 | (100) | 80 | (92) |
RDH5 | NM_002905 | 6,716 | (90) | 78 | (92) |
RLBP1 | NM_000326 | 43,011 | (99) | 74 | (91) |
intermediate interindividual variation (CV 10 th – 90 th percentile) | |||||
PRCD | AK054729 | 46,964 | (99) | 66 | (88) |
GUCY2D | NM_000180 | 2,672 | (75) | 64 | (87) |
NPHP3 | AI200954 | 3,266 | (79) | 63 | (86) |
IMPDH1 | NM_000883 | 12,177 | (95) | 63 | (86) |
LRAT | NM_004744 | 15,935 | (96) | 62 | (86) |
LRP5 | NM_002335 | 519 | (37) | 62 | (86) |
RD3 | AV721413 | 11,010 | (95) | 61 | (86) |
RGR | NM_002921 | 39,454 | (99) | 57 | (83) |
TULP1 | NM_003322 | 6,284 | (89) | 57 | (83) |
AHI1 | AL136797 | 7,168 | (91) | 56 | (82) |
SEMA4A | NM_022367 | 2,824 | (76) | 54 | (80) |
TEAD1 | AL133574 | 4,473 | (84) | 51 | (78) |
PANK2 | NM_024960 | 273 | (20) | 48 | (75) |
PEX7 | NM_000288 | 1,734 | (65) | 48 | (75) |
OAT | NM_000274 | 3,762 | (81) | 45 | (71) |
CDH3 | NM_001793 | 9,589 | (93) | 45 | (71) |
BBS10 | NM_024685 | 1,556 | (63) | 45 | (71) |
PRPF8 | NM_006445 | 6,510 | (90) | 40 | (64) |
TIMM8A | NM_004085 | 913 | (50) | 39 | (63) |
FZD4 | NM_012193 | 7,964 | (92) | 39 | (62) |
OPA3 | NM_025136 | 20,540 | (97) | 39 | (62) |
COL11A1 | NM_001854 | 911 | (50) | 38 | (61) |
PGK1 | NM_000291 | 12,114 | (95) | 37 | (59) |
CYP4V2 | AK022114 | 5,411 | (87) | 37 | (58) |
JAG1 | NM_000214 | 1,394 | (60) | 35 | (53) |
MYO7A | NM_000260 | 6,691 | (90) | 34 | (53) |
BBS2 | NM_031885 | 4,446 | (84) | 34 | (51) |
PAX2 | NM_003990 | 2,946 | (77) | 33 | (50) |
BBS1 | NM_024649 | 3,750 | (81) | 32 | (46) |
NYX | NM_022567 | 372 | (28) | 32 | (45) |
ABCC6 | NM_001171 | 1,555 | (63) | 28 | (35) |
MERTK | NM_006343 | 4,763 | (85) | 28 | (35) |
ARL6 | BI914103 | 1,023 | (53) | 28 | (34) |
MFRP | NM_031433 | 13,200 | (96) | 27 | (33) |
PXMP3 | NM_000318 | 5,341 | (87) | 25 | (25) |
ALMS1 | AB002326 | 962 | (51) | 23 | (20) |
MKKS | NM_018848 | 2,056 | (69) | 22 | (16) |
NDP | NM_000266 | 1,335 | (59) | 20 | (14) |
PHYH | NM_006214 | 3,293 | (79) | 20 | (12) |
WFS1 | NM_006005 | 4,935 | (86) | 19 | (10) |
low interindividual variation (CV < 10 th percentile) | |||||
PRPF31 | NM_015629 | 3,187 | (78) | 17 | (06) |
PEX1 | NM_000466 | 3,008 | (77) | 15 | (04) |
PRPF3 | NM_004698 | 7,057 | (91) | 14 | (03) |
TRIM32 | NM_012210 | 2,277 | (71) | 13 | (02) |
CLN3 | NM_000086 | 2,330 | (72) | 8 | (0) |