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Table 6 Expression levels and interindividual differences of currently known peripheral disease genes with RPE expression[26].

From: Functional annotation of the human retinal pigment epithelium transcriptome

gene symbol Genbank accession mean intensity (μint) (percentile) CV (percentile)
high interindividual variation (CV > 90 th percentile)
COL9A1 NM_001851 5,628 (88) 225 (100)
RBP4 NM_006744 20,291 (97) 196 (100)
COL2A1 NM_001844 527 (37) 122 (97)
GNAT1 NM_000172 100,271 (100) 80 (92)
RDH5 NM_002905 6,716 (90) 78 (92)
RLBP1 NM_000326 43,011 (99) 74 (91)
intermediate interindividual variation (CV 10 th – 90 th percentile)
PRCD AK054729 46,964 (99) 66 (88)
GUCY2D NM_000180 2,672 (75) 64 (87)
NPHP3 AI200954 3,266 (79) 63 (86)
IMPDH1 NM_000883 12,177 (95) 63 (86)
LRAT NM_004744 15,935 (96) 62 (86)
LRP5 NM_002335 519 (37) 62 (86)
RD3 AV721413 11,010 (95) 61 (86)
RGR NM_002921 39,454 (99) 57 (83)
TULP1 NM_003322 6,284 (89) 57 (83)
AHI1 AL136797 7,168 (91) 56 (82)
SEMA4A NM_022367 2,824 (76) 54 (80)
TEAD1 AL133574 4,473 (84) 51 (78)
PANK2 NM_024960 273 (20) 48 (75)
PEX7 NM_000288 1,734 (65) 48 (75)
OAT NM_000274 3,762 (81) 45 (71)
CDH3 NM_001793 9,589 (93) 45 (71)
BBS10 NM_024685 1,556 (63) 45 (71)
PRPF8 NM_006445 6,510 (90) 40 (64)
TIMM8A NM_004085 913 (50) 39 (63)
FZD4 NM_012193 7,964 (92) 39 (62)
OPA3 NM_025136 20,540 (97) 39 (62)
COL11A1 NM_001854 911 (50) 38 (61)
PGK1 NM_000291 12,114 (95) 37 (59)
CYP4V2 AK022114 5,411 (87) 37 (58)
JAG1 NM_000214 1,394 (60) 35 (53)
MYO7A NM_000260 6,691 (90) 34 (53)
BBS2 NM_031885 4,446 (84) 34 (51)
PAX2 NM_003990 2,946 (77) 33 (50)
BBS1 NM_024649 3,750 (81) 32 (46)
NYX NM_022567 372 (28) 32 (45)
ABCC6 NM_001171 1,555 (63) 28 (35)
MERTK NM_006343 4,763 (85) 28 (35)
ARL6 BI914103 1,023 (53) 28 (34)
MFRP NM_031433 13,200 (96) 27 (33)
PXMP3 NM_000318 5,341 (87) 25 (25)
ALMS1 AB002326 962 (51) 23 (20)
MKKS NM_018848 2,056 (69) 22 (16)
NDP NM_000266 1,335 (59) 20 (14)
PHYH NM_006214 3,293 (79) 20 (12)
WFS1 NM_006005 4,935 (86) 19 (10)
low interindividual variation (CV < 10 th percentile)
PRPF31 NM_015629 3,187 (78) 17 (06)
PEX1 NM_000466 3,008 (77) 15 (04)
PRPF3 NM_004698 7,057 (91) 14 (03)
TRIM32 NM_012210 2,277 (71) 13 (02)
CLN3 NM_000086 2,330 (72) 8 (0)
  1. Data are grouped by coefficient of variation (CV) in descending order into three groups, high CV (> 90th percentile, CV > 72), an intermediate group (CV 10th – 90th percentile) and CV low (< 10th percentile, CV < 19).