Phylogenetic relationship of the different CYP2 clan members. Three CYP2 clades are observed; two that contain arthropod CYP2 members and one that does not. In addition, the CYP2 clan is expanded in Daphnia pulex because of expansion of the Cyp370 family. An (H) after the CYP name denotes human sequences, a (B) denotes honeybee sequences, a (M) denotes fruitfly sequences, CYP names lacking a letter are D. pulex sequences, and anemone sequences are noted with their GenBank protein accession numbers (start with XM). Numbers at nodes are posterior probabilities.