Probability of rejecting the null hypothesis that the sequences of the SMARCAL1 conserved domains have evolved with the same pattern of substitution, as judged from the extent of differences in base composition biases between sequences (Disparity Index test). A Monte Carlo test (1000 replicates) was used to estimate the P-values, which are shown below the diagonal. P-values smaller than 0.05 are considered significant. The estimates of the disparity index per site are shown for each sequence pair above the diagonal. All positions containing gaps and missing data were eliminated from the dataset. A. First HARP domain: there were a total of 57 positions in the final dataset. B. Second HARP domain: there were a total of 62 positions in the final dataset. C. SNF2N domain: there were a total of 290 positions in the final dataset. D. Helicase C-terminal domain: there were a total of 78 positions in the final dataset. Black colored numbers: Probability computed (must be < 0.05 for hypothesis rejection at 5% level [yellow background]), Blue colored numbers: Disparity Index.