TY - JOUR AU - Walker, Angela M. AU - Roberts, R. Michael PY - 2009 DA - 2009/04/24 TI - Characterization of the bovine type I IFN locus: rearrangements, expansions, and novel subfamilies JO - BMC Genomics SP - 187 VL - 10 IS - 1 AB - The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to expansion in the number and complexity of their genes, although these genes have remained confined to single chromosomal region in all mammals so far examined. IFNB and IFNE define the limits of the locus, with all other Type I IFN genes except IFNK distributed between these boundaries, strongly suggesting that the locus has broadened as IFN genes duplicated and then evolved into a series of distinct families. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-10-187 DO - 10.1186/1471-2164-10-187 ID - Walker2009 ER -