Table 1 Completely sequenced strains of Streptococcus pyogenes used in this study. M protein type, size, number of SSRs, associated diseases, accession number as well as references are summarized.

1

SF370

1

1,852,441

5

[GenBank:NC_002737]

Pharyngitis and invasive disease

[26]

2

MGAS5005

1

1,838,554

4

[GenBank:NC_007297]

Sepsis and meningitis

[44]

3

MGAS10270

2

1,928,554

6

[GenBank:NC_008022]

[36]

4

MGAS315

3

1,900,521

7

[GenBank:NC_004070]

Streptococcal toxic shock syndrome

[37]

5

SSI-1

3

1,894,275

7

[GenBank:NC_004606]

[39]

6

MGAS10750

4

1,937,111

6

[GenBank:NC_008024]

[36]

7

Manfredo

5

1,841,271

6

[GenBank:NC_009332]

Acute rheumatic fever

[41]

8

MGAS10394

6

1,899,877

9

[GenBank:NC_006086]

[27]

9

MGAS2096

12

1,860,355

4

[GenBank:NC_008023]

Pharyngitis

[36]

10

MGAS9429

12

1,836,467

4

[GenBank:NC_008021]

[36]

11

MGAS8232

18

1,895,017

6

[GenBank:NC_003485]

Acute rheumatic fever

[40]

12

MGAS6180

28

1,897,573

6

[GenBank:NC_007296]

Puerperal sepsis

[29]