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Figure 3 | BMC Genomics

Figure 3

From: Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy

Figure 3

Real-time PCR analysis of Atrogin-1 and MuRF1. qRT-PCR analysis of Atrogin-1 (A) and MuRF1 (B) gene expression in RNA samples from Tg(HQK) mice relative to similarly treated wild-type control mice. Measurements of relative gene expression for 4 time points (over 4–60 days) in mice following treatment with 6 g Dox/kg food beginning on day 0. Total RNA was extracted from skeletal muscles (quadriceps) from the hind legs and subjected qRT-PCR analysis. Results represent the mean ± s.e.m. of triplicate measurements performed. * p < 0.01; ** p < 0.001.

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