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Table 2 Genes specifically affected by organophosphorus pesticide exposure

From: Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans

Probe Set

WBIDa

Geneb

Description

Biological Role

Dicc

Fend

191443_at

WBGene00013078

ttr-25

unknown function – contains transthyretin-like family domain

 

-5.1

-5.6

192157_at

WBGene00000964

dhp-2

dihydropyrimidinase

 

-2.7

-2.4

187663_at

WBGene00008706

F11E6.1

glucocerebrosidase

Lipid metabolism

-2.4

-2.3

173412_s_at

WBGene00013077

ttr-24

unknown function – contains transthyretin-like family domain

 

-2.5

-1.9

181137_at

WBGene00009796

F46G10.1

unknown function – contains potassium channel tetramerization domain

 

-2.2

-1.7

192644_at

WBGene00002010

hsp-6

heat shock 70 protein

Stress

-1.8

-1.8

184978_at

WBGene00003130

map-2

methionine aminopeptidase

Anti-apoptosis

-1.8

-1.6

191082_at

WBGene00009165

F26E4.12

glutathione peroxidase

Redox

-1.6

-1.9

183671_at

WBGene00019058

F58F9.4

unknown function – contains DUF272 domain

 

-1.7

-1.5

185811_at

WBGene00022194

Y71H2B.4

unknown function

 

-1.7

-1.4

178599_at

WBGene00004997

spp-12

saposin like protein family

Lipid metabolism

-1.1

-1.2

193531_at

WBGene00001668

gpa-6

G protein alpha subunit involved in chemosensation

Sensory

1.7

1.3

183021_at

WBGene00018615

F48G7.4

unknown function

 

1.9

1.3

186977_at

WBGene00014033

ZK643.1

arrestin like protein

Sensory

1.9

1.6

175989_at

WBGene00017042

D2007.2

unknown function – contains MSP domain

Axon Guidance

1.9

1.5

180587_at

WBGene00018288

F41E6.7

unknown function

 

2.0

1.7

176365_at

WBGene00022479

fbxa-36

F-box A protein

Ubiquitination

2.4

1.4

193559_s_at

WBGene00003644

nhr-54

nuclear hormone receptor-54

Transcription factor

1.3

1.5

185495_at

WBGene00016094

C25E10.4

predicted transporter/transmembrane protein

Membrane channel

1.6

1.4

193861_at

WBGene00006614

trp-1

transient receptor potential ion channel involved in sensory transduction

Sensory, membrane channel

1.5

1.5

188133_at

WBGene00004226

ptr-12

patch related family

Sterol trafficking

1.7

1.7

179248_at

WBGene00008693

F11C1.4

unknown function

 

1.6

1.4

184849_at

WBGene00020869

T28A11.2

unknown function – contains DUF19 domains

 

1.8

1.5

179132_at

WBGene00007854

C31H5.1

alpha/beta hydrolase of unknown function

Sensory

1.4

1.8

178276_at

WBGene00007421

C07H4.1

unknown function

 

1.7

1.4

175147_at

WBGene00000969

dhs-5

dehydrogenase, short chain – possible steroid dehydrogenase

Detoxification

1.2

1.8

174374_s_at

WBGene00018576

F47G3.1

unknown function

Sensory

1.4

1.9

192917_s_at

WBGene00008547

F07A11.4

ubiquitin carboxyl-terminal hydrolase

Ubiquitination

1.6

2.1

192646_at

WBGene00010396

H13N06.2

unknown function – contains VWA invertebrate integrin domain

 

1.5

1.5

191570_s_at

WBGene00009717

dep-1

class III receptor protein tyrosine phosphatase (R-PTP)

Signaling

1.6

1.8

193155_s_at

WBGene00009781

F46C5.6

unknown function – contains 2 HEAT repeat domains

 

1.8

1.9

187505_at

WBGene00015139

B0310.3

unknown function

 

1.2

2.0

179197_s_at

WBGene00007672

fbxa-136

F-box A protein

Ubiquitination

1.6

2.1

189341_s_at

WBGene00013875

ZC376.3

b-type carboxylesterase

Detoxification

1.7

2.1

185117_at

WBGene00016657

C44E12.1

N-acyl-L-amino-acid amidohydrolase

Amino acid metabolism

1.7

2.5

193763_at

WBGene00009854

clec-31

unknown function – contains 2 C-type lectin domains

 

2.1

1.5

186028_at

WBGene00015371

C03A7.13

UDP-glucuronosyl/glucosyl transferase

Detoxification

2.1

1.6

177226_s_at

WBGene00022016

Y61A9LA.4

unknown function

 

2.4

1.5

189292_at

WBGene00019438

cyp-25A6

cytochrome P450

Detoxification

2.4

1.7

191150_at

WBGene00006486

tag-140

predicted Zn transporter

Membrane channel

1.7

1.7

178686_s_at

WBGene00013885

ZC412.4

unknown function

 

1.7

1.6

181726_at

WBGene00002140

inx-18

innexin – invertebrate gap junction protein

Membrane channel

1.8

1.8

188880_at

WBGene00007924

C34C12.5

Ras suppressor protein

Cell Adhesion

1.9

1.8

188007_at

WBGene00006984

zig-7

2(Zwei) IG-domain protein

Cell Adhesion

1.7

1.8

193031_at

WBGene00011556

T07A5.3

sugar phosphate permease

Membrane channel

2.1

1.5

191623_at

WBGene00020182

ugt-53

UDP-glucuronosyl/glucosyl transferase

Detoxification

2.3

1.8

186581_at

WBGene00013819

Y116F11A.6

unknown function – contains caspase recruitment domain

Apoptosis/Cell Death

2.5

1.7

188459_s_at

WBGene00000779

cpn-3

Calponin

Actin related

2.0

2.1

177598_at

WBGene00012034

T26C5.4

unknown function

 

2.1

2.1

176229_at

WBGene00018367

F42H10.3

unknown function – contains Nebulin repeat domain

Actin related, Cell Adhesion

2.1

2.0

193302_at

WBGene00010675

K08E7.8

unknown function – contain leucine rich repeat domain

Apoptosis/Cell Death

2.0

2.1

183894_at

WBGene00015889

C17C3.3

acyl co-A thioesterase

Lipid metabolism

3.1

2.4

189169_s_at

WBGene00001480

fmo-5

flavin-containing monooxygenase

Detoxification

3.1

1.6

175285_at

WBGene00018747

F53C3.3

unknown function – contains CX module

 

3.3

2.1

188099_s_at

WBGene00006582

tmd-2

Tropomodulin

Actin related

2.8

2.4

173824_at

WBGene00022788

ZK682.2

sugar phosphate permease

Membrane channel

2.7

2.5

190692_at

WBGene00012322

W07A12.4

unknown function – contains btb/poz domain

Ubiquitination

2.4

2.3

189557_at

WBGene00015062

trx-1

Thioredoxin

Redox

3.2

1.7

193582_at

WBGene00003629

nhr-38

nuclear hormone receptor involved in thermosensation

Sensory

2.4

2.1

178886_at

WBGene00009328

F32D8.3

unknown function – contains trypsin Inhibitor like cysteine rich domain

 

3.1

2.4

190432_at

WBGene00001608

R07B1.8

unknown function – contains GTP binding domain

 

1.9

2.2

190957_at

WBGene00001763

gst-15

glutathione S-transferase

Redox

2.2

2.1

188131_s_at

WBGene00006318

sup-9

TWK potassium channel

Membrane channel

2.4

1.9

184319_at

WBGene00000780

cpn-4

Calponin

Actin related

2.5

2.1

190211_at

WBGene00008746

dpy-30

adenylate kinase like

 

2.5

2.5

177839_s_at

WBGene00013481

Y69H2.3

unknown function – contains trypsin inhibitor like cysteine rich domain

 

2.3

2.3

192432_at

WBGene00008028

scl-6

defense-related protein containing SCP domain

 

2.4

2.7

191916_at

WBGene00015559

C06G4.5

G-protein coupled receptor

 

2.5

2.6

190719_at

WBGene00017332

ugt-37

UDP-glucuronosyl/glucosyl transferase

Detoxification

1.6

4.2

192997_s_at

WBGene00018832

pat-2

vitronectin receptor, alpha subunit

Actin related, Cell Adhesion

1.8

3.0

172944_s_at

WBGene00018720

F53A3.1

unknown function

 

2.9

3.7

193210_s_at

WBGene00006794

unc-60c

actin depolymerizing factor

Actin related

2.5

2.6

187747_at

WBGene00006814

unc-82

serine/threonine protein kinase required for thick filament organization

 

2.2

2.9

173480_s_at

WBGene00021167

cyp-32B1

cytochrome P450

Detoxification

2.5

2.2

173698_s_at

WBGene00008499

cyp-37A1

cytochrome P450

Detoxification

3.0

2.3

186562_s_at

WBGene00012875

Y45F10B.13

unknown function

 

2.8

3.3

179847_s_at

WBGene00018720

F53A3.1

unknown function

 

2.3

2.5

193108_s_at

WBGene00003485

mua-6 (ifa-2)

intermediate filament protein

Cell Adhesion

3.7

3.9

191689_s_at

WBGene00007422

ugt-17

UDP-glucuronosyl/glucosyl transferase

Detoxification

4.1

4.3

183314_at

WBGene00016210

C29F5.1

unknown function

 

4.7

5.5

178198_at

WBGene00011251

glb-22

unknown function – contains globin domain

 

4.7

3.3

186720_at

WBGene00020881

T28A11.19

predicted secreted cysteine rich protein

 

4.3

3.7

183178_at

WBGene00020690

T22E5.1

unknown function

Actin related

5.2

3.5

190445_at

WBGene00008490

F01D4.8

cysteine synthase/cystathionine beta-synthase family

Redox

6.6

1.8

185116_s_at

WBGene00019934

R07C12.4

unknown function

 

5.5

3.1

177733_at

WBGene00005654

srr-3

serpentine receptor, class R

Sensory

7.5

2.9

181201_at

WBGene00018479

F45F2.6

otopetrin like transmembrane protein

Sensory

6.7

5.1

189633_at

WBGene00015045

cyp-34A10

cytochrome P450

Detoxification

2.2

21.2

  1. a- Gene names and descriptions were derived from WormBase, release WS189 [46].
  2. b- WormBase gene identifier.
  3. c- Gene expression fold change values for dichlorvos SVM predicted high concentration
  4. d- Gene expression fold change values for fenamiphos high concentration
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BMC Genomics

ISSN: 1471-2164

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