Position of MyD88 and overlap of QTLs in cattle and mouse. QTL positions are indicated by bold blue lines. Green boxes indicate the localisation of syntenic blocks conserved among species. Inversions of the gene order are indicated by red arrows. Loci located on the boundaries of the overlap between the QTL in cattle (Tryanosoma resistance) and in mice (Plasmodium chabaudi malaria) are indicated in blue. Under the assumption that the indicated QTLs are caused by the same loci, the significant region can be narrowed to segments with a combined length of approximately 10 Mb (brown line in syntenic blocks). Immunologically relevant genes located in these regions are listed in additional file 4: Immunologically relevant genes in regions of conserved synteny surrounding the TLR1 family cluster, MyD88 and IRF3.