Position of the TLR1 family cluster and overlap of QTLs in cattle, mouse and human. QTL positions are indicated by bold blue lines. Green boxes indicate the localisation of the syntenic block conserved between species. Under the assumption that the indicated QTLs are caused by the same loci, the significant region can be narrowed to a segments with a length of approximately 20 Mb (brown line in syntenic blocks). Two loci (GPR125 and YIP7, in blue) limit the overlap of the QTL for susceptibility to clinical mastitis in cattle with the QTL for Listeria monocytogenes susceptibility in mice. Polymorphisms in human TLR6 (red, within the QTL overlap) have been associated with susceptibility to tuberculosis. Immunologically relevant genes located in this region are listed in additional file 4: Immunologically relevant genes in regions of conserved synteny surrounding the TLR1 family cluster, MyD88 and IRF3.