Figure 7
Structural-based multiple sequence alignment. Using human α1-antitrypsin (1hbp7) as modeling template, five serpin sequences (S1, S19, S22, S34 and S35) representing each of the five main branches in figure 4 were aligned using the structural based sequence alignment program (STRAP, http://www.charite.de/bioinf/strap). Secondary structures assigned based on α1-antitrypsin tertiary structure (PDB ID, 1hbp7), are labeled as "H" for α-helix and "E" for beta-strand. Helices are labeled from "hA" to "hI", β-strands that constitutes β-sheet A-to-C are labeled as "sA", "sB" and "sC" respectively. The serpin superfamily core residues [52] are shaded in black. The reactive center loop domain is noted.