Figure 1
From: Computational prediction of cAMP receptor protein (CRP) binding sites in cyanobacterial genomes
(a) Phylogenetic relationships of CRPs from 12 cyanobacterial genomes. The tree is rooted with the CRP of E. coli K12, and bootstrap values are shown on the nodes. (b) Multiple sequence alignments of the DNA binding domains of the 12 cyanobacterial CRPs. The DNA binding domains contains a helix-turn-helix motif in which residues 1–9 form the first helix, residues 10–12 form the turn and residues 13–25 form the second helix. Particularly, residues 13–21 form the DNA recognition helix with residues 13, 14, 18 (indicated by solid dots) being in direct contact with DNA through forming hydrogen bonds with it [39]. (c). Logo representation of the profile of the 112 putative CRP binding sites predicted by the phylogenetic footprinting technique. Logo was generated by the Weblogo server [49].