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Table 1 Cellular metabolism and cancer processes affected by genes that are differentially expressed in tumors caused by the different transgenic STAT5 variants.

From: Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5

Category

Process

Process Annotation

Significance

No. of Molecules

Carbohydrate Metabolism

formation

formation of inositol phosphate

1.53-2

3

 

production

production of carbohydrate

8.32-3

7

 

transport

transport of carbohydrate

1.66-5

11

 

utilization

utilization of carbohydrate

1.04-2

3

Cardiovascular System Development and Function

angiogenesis

angiogenesis of cells

1.69-3

5

 

cardiovascular process

cardiovascular process of cornea

6.15-4

6

Cell cycle

G1 phase

G1 phase of eukaryotic cells

1.88-2

11

 

G2 phase

G2 phase of tumor cell lines

1.59-2

5

 

interphase

interphase of eukaryotic cells

1.36-2

17

 

length

length of telomeres

1.72-2

3

 

mitogenesis

mitogenesis

3.30-3

10

Cell death

cell death

cell death

1.43-3

74

 

cell death

cell death of cell lines

5.03-4

49

 

cell death

cell death of tumor cell lines

2.11-4

41

Cellular Assembly and Organization

formation

formation of cellular protrusions

1.18-2

7

  

formation of filopodia

7.48-4

8

  

formation of plasma membrane projections

1.77-3

13

 

growth

growth of plasma membrane projections

1.21-2

13

Cellular Growth and Proliferation

formation

formation of eukaryotic cells

2.93-3

13

 

growth

growth of cell lines

4.41-4

36

 

proliferation

proliferation of eukaryotic cells

1.58-6

65

Cellular Movement

cell movement

cell movement of eukaryotic cells

1.25-3

45

  

cell movement of tumor cell lines

1.23-4

22

 

homing

homing of eukaryotic cells

5.69-3

17

 

migration

migration of tumor cell lines

2.23-4

17

DNA Replication, Recombination and Repair

synthesis

synthesis of DNA

3.78-3

17

Hematological System Development and Function

hematological process

hematological process

7.64-3

24

Nervous System Development and Function

growth

growth of neurites

1.02-2

13

Tissue Morphology

contraction

contraction of tissue

6.01-4

12

Cancer

benign tumor

benign tumor

1.55-2

10

 

carcinoma in situ

carcinoma in situ

1.77-2

6

 

apoptosis

apoptosis of tumor cell lines

2.33-4

37

 

cell death

cell death of tumor cell lines

2.11-4

41

  

cell death of breast cancer cell lines

1.12-2

11

 

cell movement

cell movement of tumor cell lines

1.23-4

22

 

growth

growth of tumor

2.03-3

10

  

growth of tumor cell lines

1.01-2

25

 

metastasis

migration of tumor cell lines

2.23-4

17

 

proliferation

proliferation of tumor cell lines

1.29-4

28

 

transformation

transformation of cells

1.31-2

19

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BMC Genomics

ISSN: 1471-2164

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