Table 1 The 60 most up- and down-regulated transcripts in Itk-deficiency (unstimulated cells)
From: Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
Probe set | Gene Symbol, Gene Title | Itk-/- vs Wt | t-test |
|---|---|---|---|
1453196_a_at | Oasl2, 2'-5' oligoadenylate synthetase-like 2 | -7.91 | 0.008 |
1448327_at | Actn2, actinin alpha 2 | -3.97 | 0.016 |
1437445_at | Trpm1, transient receptor potential cation channel, subfamily M, member 1 | -3.72 | 0.051 |
1445450_x_at | A530021J07Rik | -3.71 | 0.012 |
1421234_at | Hnf1a, HNF1 homeobox A | -3.45 | 0.044 |
1448485_at | Ggt1, gamma-glutamyltransferase 1 | -3.39 | 0.005 |
1445194_at | Cnksr2, connector enhancer of kinase suppressor of Ras 2 | -3.31 | 0.034 |
1418545_at | Wasf1, WASP family 1 | -3.01 | 0.016 |
1451548_at | Upp2, uridine phosphorylase 2 | -2.91 | 0.049 |
1434722_at | Ampd1, adenosine monophosphate deaminase 1 | -2.85 | 0.004 |
1436836_x_at | Cnn3, calponin 3, acidic | -2.79 | 0.005 |
1429274_at | 2310010M24Rik | -2.46 | 0.001 |
1455442_at | Slc6a19, solute carrier family 6 member 19 | -2.34 | 0.005 |
1432383_a_at | Armc9, armadillo repeat containing 9 | -2.29 | 0.020 |
1417928_at | Pdlim4, PDZ and LIM domain 4 | -2.28 | 0.055 |
1444801_at | 2900041M22Rik | -2.27 | 0.029 |
1443570_at | Cops3, COP9 (constitutive photomorphogenic) homolog, subunit 3 | -2.25 | 0.005 |
1421895_at | Eif2s3x, eukaryotic translation initiation factor 2, subunit 3 | -2.25 | 0.013 |
1418055_at | Neurod4, neurogenic differentiation 4 | -2.23 | 0.020 |
1453009_at | Gene name not assigned for this probe set | -2.22 | 0.014 |
1429350_at | Eid3, EP300 interacting inhibitor of differentiation 3 | -2.21 | 0.039 |
1420877_at | Sept6, septin 6 | -2.17 | 0.001 |
1438825_at | Calm3, Calmodulin 3 | -2.16 | 0.022 |
1434915_s_at | Lrrc19, leucine rich repeat containing 19 | -2.12 | 0.041 |
1436103_at | Rab3ip, RAB3A interacting protein | -2.12 | 0.006 |
1456751_x_at | A530021J07Rik | -2.12 | 0.000 |
1439254_at | Gene name not assigned for this probe set | -2.11 | 0.037 |
1418003_at | 1190002H23Rik | -2.11 | 0.037 |
1449634_a_at | Anks1b, ankyrin repeat and sterile alpha motif domain containing 1B | -2.09 | 0.047 |
1418990_at | Ms4a4d, membrane-spanning 4-domains, subfamily A, member 4D | -2.09 | 0.031 |
1421182_at | Clec1b, C-type lectin domain family 1, member b | 3.7 | 0.038 |
1424842_a_at | Arhgap24, Rho GTPase activating protein 24 | 3.74 | 0.014 |
1418340_at | Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide | 3.76 | 0.016 |
1444214_at | Tubb1, tubulin, beta 1 | 3.79 | 0.044 |
1452666_a_at | Tmcc2, transmembrane and coiled-coil domains 2 | 3.88 | 0.033 |
1457001_at | Cenpk, centromere protein K | 3.9 | 0.004 |
1449340_at | Sostdc1, sclerostin domain containing 1 | 3.91 | 0.014 |
1434115_at | Cdh13, cadherin 13 | 3.95 | 0.054 |
1434955_at | March1, membrane-associated ring finger (C3HC4) 1 | 4.04 | 0.000 |
1439397_at | Fmn1, formin 1 | 4.06 | 0.026 |
1448749_at | Plek, pleckstrin | 4.13 | 0.010 |
1426171_x_at | Klra7, killer cell lectin-like receptor, subfamily A, member 7 | 4.14 | 0.003 |
1436778_at | Cybb, cytochrome b-245, beta polypeptide | 4.15 | 0.012 |
1448025_at | Sirpb1, signal-regulatory protein beta 1 | 4.2 | 0.046 |
1420789_at | Klra5, killer cell lectin-like receptor, subfamily A, member 5 | 4.22 | 0.018 |
1441887_x_at | EG622976 | 4.26 | 0.017 |
1438553_x_at | Gene name not assigned for this probe set | 4.28 | 0.011 |
1417765_a_at | Amy1, amylase 1, salivary | 4.29 | 0.016 |
1451263_a_at | Fabp4, fatty acid binding protein 4 | 4.32 | 0.020 |
1427866_x_at | Gene name not assigned for this probe set | 4.43 | 0.037 |
1454200_at | Zeb2, zinc finger E-box binding homeobox 2 | 4.57 | 0.022 |
1420492_s_at | Smr3a, submaxillary gland androgen regulated protein 3A | 4.79 | 0.006 |
1427503_at | AI324046 | 4.85 | 0.024 |
1437463_x_at | Tgfbi, transforming growth factor, beta induced | 5.04 | 0.005 |
1419348_at | Psp, parotid secretory protein | 5.11 | 0.019 |
1419874_x_at | Zbtb16, zinc finger and BTB domain containing 16 | 5.46 | 0.005 |
1442025_a_at | Gene name not assigned for this probe set | 5.48 | 0.002 |
1449501_a_at | Gzmm, granzyme M | 6.39 | 0.013 |
1425436_x_at | Klra3, killer cell lectin-like receptor, subfamily A, member 3 | 9.92 | 0.000 |
1425417_x_at | Klra8, killer cell lectin-like receptor, subfamily A, member 8 | 35.69 | 0.000 |