Table 5 The 60 most up- and down-regulated transcripts in Itk-defective CD4+ T-cells (unstimulated cells)
From: Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
Probe set | Gene Symbol, Gene Title | Itk-/- vs Wt | t-test |
|---|---|---|---|
1436386_x_at | OTTMUSG00000010671 | -7.51 | 0.012 |
1444708_at | Tmem29, transmembrane protein 29 | -5 | 0.014 |
1434418_at | Lass6, LAG1 homolog, ceramide synthase 6 | -4.93 | 0.001 |
1438354_x_at | Cnn3, Calponin 3, acidic | -4.81 | 0.030 |
1430988_at | 2810407C02Rik | -3.84 | 0.028 |
1430827_a_at | Ptk2, PTK2 protein tyrosine kinase 2 | -3.68 | 0.002 |
1458977_at | A530021J07Rik | -3.36 | 0.006 |
1439778_at | Cables1, Cdk5 and Abl enzyme substrate 1 | -3.26 | 0.018 |
1427675_at | V1ra2, vomeronasal 1 receptor, A2 | -3.22 | 0.041 |
1448338_at | Pgcp, plasma glutamate carboxypeptidase | -3.16 | 0.001 |
1458945_at | AU015148 | -3.16 | 0.038 |
1421507_at | Olfr78, olfactory receptor 78 | -3.07 | 0.021 |
1457120_at | Itk, IL2-inducible T-cell kinase | -2.96 | 0.002 |
1456178_at | Bambi-ps1, BMP and activin membrane-bound inhibitor, pseudogene (Xenopus laevis) | -2.94 | 0.000 |
1455907_x_at | Phox2b, paired-like homeobox 2b | -2.88 | 0.050 |
1452474_a_at | Art3, ADP-ribosyltransferase 3 | -2.86 | 0.026 |
1459508_at | C85600 | -2.79 | 0.007 |
1440761_at | 4833422C13Rik | -2.77 | 0.052 |
1446412_at | Gene name not assigned for this probe set | -2.71 | 0.012 |
1441221_at | Gene name not assigned for this probe set | -2.7 | 0.019 |
1427632_x_at | Cd55, CD55 antigen | -2.65 | 0.042 |
1439181_at | BC043301 | -2.63 | 0.032 |
1434473_at | Slc16a5, solute carrier family 16 (monocarboxylic acid transporters), member 5 | -2.59 | 0.001 |
1448002_x_at | 2610001J05Rik | -2.57 | 0.018 |
1455425_at | BB001228 | -2.57 | 0.016 |
1419620_at | Pttg1, pituitary tumor-transforming 1 | -2.53 | 0.000 |
1453009_at | Gene name not assigned for this probe set | -2.39 | 0.000 |
1455740_at | Hnrnpa1, heterogeneous nuclear ribonucleoprotein A1 | -2.31 | 0.048 |
1429413_at | Cpm, carboxypeptidase M | -2.28 | 0.003 |
1416441_at | Pgcp, plasma glutamate carboxypeptidase | 3.12 | 0.005 |
1425216_at | Ffar2, free fatty acid receptor 2 | 3.13 | 0.036 |
1448471_a_at | Ctla2a, cytotoxic T lymphocyte-associated protein 2 alpha | 3.13 | 0.006 |
1450334_at | Il21, interleukin 21 | 3.13 | 0.013 |
1423091_a_at | Gpm6b, glycoprotein m6b | 3.21 | 0.032 |
1435339_at | Kctd15, potassium channel tetramerisation domain containing 15 | 3.24 | 0.044 |
1428197_at | Tspan9, tetraspanin 9 | 3.37 | 0.001 |
1449036_at | Rnf128, ring finger protein 128 | 3.44 | 0.002 |
1449361_at | Tbx21, T-box 21 | 3.5 | 0.012 |
1447839_x_at | Adm, adrenomedullin | 3.62 | 0.031 |
1418318_at | Rnf128, ring finger protein 128 | 3.77 | 0.021 |
1419647_a_at | Ier3, immediate early response 3 | 3.78 | 0.005 |
1448961_at | Plscr2, phospholipid scramblase 2 | 4.06 | 0.012 |
1449280_at | Esm1, endothelial cell-specific molecule 1 | 4.15 | 0.013 |
1427445_a_at | Ttn, titin | 4.32 | 0.006 |
1425471_x_at | Gene name not assigned for this probe set | 4.33 | 0.050 |
1438553_x_at | Gene name not assigned for this probe set | 4.35 | 0.019 |
1423231_at | Nrgn, neurogranin | 4.66 | 0.002 |
1416846_a_at | Pdzrn3, PDZ domain containing RING finger 3 | 4.69 | 0.002 |
1430946_at | 2600014E21Rik | 4.82 | 0.031 |
1426001_at | Eomes, eomesodermin homolog (Xenopus laevis) | 5.43 | 0.024 |
1422280_at | Gzmk, granzyme K | 5.6 | 0.002 |
1427608_a_at | Tcrg-V1, T-cell receptor gamma, variable 1 | 5.62 | 0.044 |
1434194_at | Mtap2, microtubule-associated protein 2 | 5.71 | 0.040 |
1434115_at | Cdh13, cadherin 13 | 6.15 | 0.047 |
1455435_s_at | Chdh, choline dehydrogenase | 6.54 | 0.041 |
1449864_at | Il4, interleukin 4 | 6.77 | 0.031 |
1424011_at | Aqp9, aquaporin 9 | 7.23 | 0.011 |
1420678_a_at | Il17rb, interleukin 17 receptor B | 9.84 | 0.029 |
1442025_a_at | Gene name not assigned for this probe set | 11.69 | 0.008 |
1419874_x_at | Zbtb16, zinc finger and BTB domain containing 16 | 12.07 | 0.009 |