Table 6 The 60 most up- and down-regulated transcripts in Itk-defective CD8+ T-cells (unstimulated cells)
From: Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells
Probe set | Gene Symbol, Gene Title | Itk-/- vs Wt |
|---|---|---|
1417852_x_at | Clca1, chloride channel calcium activated 1 | -68.71 |
1419874_x_at | Zbtb16, zinc finger and BTB domain containing 16 | -45.13 |
1436759_x_at | Cnn3, calponin 3, acidic | -39.91 |
1454869_at | Wdr40b, WD repeat domain 40B | -34.02 |
1427054_s_at | Abi3bp, ABI gene family, member 3 (NESH) binding protein | -31.51 |
1437992_x_at | Gja1, gap junction protein, alpha 1 | -25.36 |
1416203_at | Aqp1, aquaporin 1 | -24.68 |
1437279_x_at | Sdc1, syndecan 1 | -24.33 |
1448182_a_at | Cd24a, CD24a antigen | -21.41 |
1456956_at | Ikzf2, IKAROS family zinc finger 2 | -19.8 |
1442025_a_at | Gene name not assigned for this probe set | -19.78 |
1439422_a_at | C1qdc2, C1q domain containing 2 | -19.69 |
1454086_a_at | Lmo2, LIM domain only 2 | -18.62 |
1416330_at | Cd81, CD81 antigen | -17.08 |
1451867_x_at | Arhgap6, Rho GTPase activating protein 6 | -17.08 |
1456060_at | Maf, avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog | -16.84 |
1419014_at | Rhag, Rhesus blood group-associated A glycoprotein | -16.79 |
1416193_at | Car1, carbonic anhydrase 1 | -16.49 |
1450744_at | Ell2, elongation factor RNA polymerase II 2 | -14.83 |
1456147_at | St8sia6, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -14.78 |
1456475_s_at | Prkar2b, protein kinase, cAMP dependent regulatory, type II beta | -14.57 |
1460431_at | Gcnt1, glucosaminyl (N-acetyl) transferase 1, core 2 | -14.03 |
1437171_x_at | Gsn, gelsolin | -13.64 |
1417777_at | Ltb4dh, leukotriene B4 12-hydroxydehydrogenase | -13.54 |
1437935_at | 4930486G11Rik | -13.51 |
1434499_a_at | Ldhb, lactate dehydrogenase B | -13.44 |
1450333_a_at | Gata2, GATA binding protein 2 | -13.33 |
1423569_at | Gatm, glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -12.94 |
1435884_at | Itsn1, intersectin 1 (SH3 domain protein 1A) | -12.72 |
1425145_at | Il1rl1, interleukin 1 receptor-like 1 | -12.6 |
1449313_at | Klk1b5, kallikrein 1-related peptidase b5 | 13.38 |
1454106_a_at | Cxxc1, CXXC finger 1 (PHD domain) | 13.41 |
1442639_at | Gene name not assigned for this probe set | 13.76 |
1443006_at | Gene name not assigned for this probe set | 13.93 |
1433449_at | Snx32, sorting nexin 32 | 14.78 |
1423603_at | Zfpm1, zinc finger protein, multitype 1 | 14.98 |
1441770_at | Ppat, phosphoribosyl pyrophosphate amidotransferase | 15.29 |
1420343_at | Gzmd, granzyme D | 15.42 |
1445596_at | Gene name not assigned for this probe set | 15.54 |
1452985_at | Uaca, uveal autoantigen with coiled-coil domains and ankyrin repeats | 16.55 |
1420233_at | Gene name not assigned for this probe set | 16.79 |
1423020_at | Gene name not assigned for this probe set | 17.39 |
1454481_at | Mif, macrophage migration inhibitory factor | 17.64 |
1427426_at | Kcnq5, potassium voltage-gated channel, subfamily Q, member 5 | 18.06 |
1424698_s_at | Gca, grancalcin | 18.46 |
1447574_s_at | Slc32a1, Solute carrier family 32 (GABA vesicular transporter), member 1 | 18.73 |
1431854_a_at | 4930452B06Rik | 18.94 |
1460267_at | Dmrt3, doublesex and mab-3 related transcription factor 3 | 19.76 |
1417197_at | Wwc2, WW, C2 and coiled-coil domain containing 2 | 20.76 |
1442788_at | Afap1, actin filament associated protein 1 | 20.91 |
1447292_at | Actr1b, ARP1 actin-related protein 1 homolog B (yeast) | 21.96 |
1431878_at | Grhl2, grainyhead-like 2 (Drosophila) | 22.18 |
1449501_a_at | Gzmm, granzyme M (lymphocyte met-ase 1) | 23.58 |
1436500_at | Rps24, Ribosomal protein S24 | 25.96 |
1425436_x_at | Klra3, killer cell lectin-like receptor, subfamily A, member 3 | 26.39 |
1456130_at | LOC553091 | 27.36 |
1454240_at | Nfe2l3, nuclear factor, erythroid derived 2, like 3 | 29.25 |
1422641_at | Dok5, docking protein 5 | 29.31 |
1417375_at | Tuba4a, tubulin, alpha 4A | 30.36 |
1425417_x_at | Klra8, killer cell lectin-like receptor, subfamily A, member 8 | 131.81 |