A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism

Table 2 GO term analysis of genes spanned by FcB1-schizont-ESTs.

GO term	GO ID	Genes in the FcB1-schizont collection	Genes in the whole genome	p-value
Cellular Components
nucleosome	GO:0000786	4	8	0.000334
actin cytoskeleton	GO:0015629	5	18	0.00136
myosin complex	GO:0016459	3	6	0.00208
chromosome	GO:0005694	7	45	0.00561
rhoptry	GO:0020008	2	3	0.00694
Biological Processes
entry into host cell	GO:0030260	4	7	0.000174
nucleosome assembly	GO:0006334	4	12	0.00202
cytokinesis	GO:0000910	2	2	0.00239
cytoskeleton organisation and biogenesis	GO:0007010	8	56	0.00533
DNA packaging process	GO:0006323	5	25	0.00637
cell division	GO:0051301	2	3	0.00694
cell motility	GO:0006928	2	3	0.00694
defense response	GO:0006952	1	187	0.00745
Molecular Functions
actin binding	GO:0003779	6	14	2.74e-05
phospholipid binding	GO:0005543	3	7	0.0035
calcium ion binding	GO:0005509	10	86	0.00853

A statistical analysis was performed to identify GO terms over- or under-represented in the annotated genes of this collection as compared to their distribution in the annotated genes of the whole genome. GOStat software [22] was used for this analysis, using a p-value threshold of 0.01. Only 159 genes have GO annotations among the 243 genes of the collection (3241 genes have GO annotations throughout the whole genome). This table reports all non-redundant over- or under-represented terms (i.e. all over- or under-represented GO terms that do not generalize another over- or under-represented term) in the three ontologies (cellular component, biological process, and molecular function). All terms were over-represented except for the term "defense response" (biological process) that was under-represented.

ISSN: 1471-2164