A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism

Florent, Isabelle; Porcel, Betina M; Guillaume, Elodie; Da Silva, Corinne; Artiguenave, François; Maréchal, Eric; Bréhélin, Laurent; Gascuel, Olivier; Charneau, Sébastien; Wincker, Patrick; Grellier, Philippe

doi:10.1186/1471-2164-10-235

Table 3 Gene models confirmed by FcB1-schizont-ESTs.

From: A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism

[Gene] (a)	[Product Description] (b)	[Pf-iRBC max expr time (GS array)] (c)	[Pf-iRBC+Spz+ Gam max expr stage (Affy)] (d)	# of ESTs (e)	confirmed in gene model (f)
PFA0110w	ring-infected erythrocyte surface antigen	46	Merozoite	229	intron 1
MAL13P1.103	hypothetical protein, conserved	34	Gametocyte	1	introns 1 to 4 and exons 1 to 5 *
MAL7P1.108	hypothetical protein, conserved		Early Schizogony	7	intron 3
MAL7P1.153	hypothetical protein, conserved	46	Gametocyte	2	intron 1
MAL7P1.229	Cytoadherence linked asexual protein	40		133	intron 1
PF08_0075	60S ribosomal protein L13, putative	14	Early Trophozoite	29	intron 1
PF10_0211	hypothetical protein	42	Late Schizogony	44	intron 2
PF10_0268	merozoite capping protein 1	41	Early Schizogony	8	intron 1
PF10_0372	Antigen UB05	37	Early Schizogony	7	introns 1 and 3
PF11_0348	hypothetical protein	37	Gametocyte	29	intron 1
PF13_0173	hypothetical protein, conserved	42	Late Schizogony	58	intron 1
PF14_0429	RNA helicase, putative	43	Early Ring	16	exon 1 and intron 1
PFB0310c	merozoite surface protein 4		Early Schizogony	33	intron 1
PFB0340c	cysteine protease, putative	37	Early Schizogony	582	introns 2 and 3
PFB0475c	hypothetical protein, conserved	46	Late Schizogony	40	introns 1 and 2
PFB0815w	Pf Calcium-dependent protein kinase 1	42	Late Schizogony	60	introns 1 to 4 *
PFC0120w	Cytoadherence linked asexual protein, 3.2	40	Early Schizogony	252	introns 1 to 5 *
PFC0920w	histone H2A variant, putative	39	Late Schizogony	42	introns 1 and 2
PFD0940w	hypothetical protein, conserved	38	Early Schizogony	52	intron 2
PFE1415w	cell cycle regulator with zn-finger domain, putative	40	Gametocyte	10	introns 5 to 8 *
PFF0185c	hypothetical protein	41		21	intron 14
PFI0265c	RhopH3	41	Early Schizogony	183	exons 4, 5, 6
PFI1445w	High molecular weight rhoptry protein-2	39	Early Schizogony	95	introns 1 and 6
PFL0975w	hypothetical protein, conserved	38	Early Schizogony	27	introns 3 and 4 and end of gene *
PFL1160c	hypothetical protein, conserved	39	Early Schizogony	31	introns 2 and 3
PFL2505c	hypothetical protein, conserved		Late Schizogony	107	introns 1 and 2

This table, derived from Additional file 1, lists the 26 P. falciparum genes whose gene models were confirmed by FcB1-schizont-ESTs. The first 4 columns were downloaded from PlasmoDB version 5.3 and correspond respectively to: gene accession numbers in PlasmoDB (a), their current description in PlasmoDB (b), the maximum expression time during the erythrocytic cycle according to the transcriptomic data of [17, 19] (c) and the maximum expression stage according to the transcriptomic data of [18] (d). Column (e) indicates the number of ESTs corresponding to each gene and isolated in this study. Column (f) details the genetic elements that were confirmed. Asterisks (*) in this last column refer to examples illustrated in Additional file 3. Pf-iRBC, P. falciparum-infected red blood cells.

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