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Table 1 Identification of significantly changed molecular pathways by mappfinder analysis of the significantly altered genes in both transient overexpression and transient knockdown of the ZNF191 gene.

From: A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor

GOID

Pathway Name/GO Term

NO. genes

% Changed

Z-score

Up-regulated in overexpression and down-regulated in KD

   43549

regulation of kinase activity

12

60

2.73

   45859

regulation of protein kinase activity

12

60

2.73

   165

MAPKKK cascade

8

66.7

2.60

   51338

regulation of transferase activity

12

57.1

2.51

   65008

regulation of biological quality

15

53.6

2.51

   22402

cell cycle process

21

47.7

2.32

   1525

angiogenesis

8

61.5

2.31

   6952

defense response

13

52

2.19

   6508

proteolysis

12

52.2

2.12

   48514

blood vessel morphogenesis

8

57.1

2.04

   7264

small GTPase mediated signal transduction

10

52.6

1.96

   5515

protein binding

108

36.9

2.38

   5525

GTP binding

9

60

2.36

   30246

carbohydrate binding

10

55.6

2.18

   19001

guanyl nucleotide binding

9

56.3

2.11

   5783

endoplasmic reticulum

15

48.4

2.01

Down-regulated in overexpression and up-regulated in KD

   6066

alcohol metabolic process

14

100

2.56

   45449

regulation of transcription

95

77.9

2.45

   9719

response to endogenous stimulus

17

94.4

2.40

   6974

response to DNA damage stimulus

17

94.4

2.40

   19219

regulation of nucleobase\, nucleoside\, nucleotide and nucleic acid metabolic process

95

77.2

2.30

   7420

brain development

11

100

2.27

   6355

regulation of transcription\, DNA-dependent

89

77.4

2.25

   6350

transcription

96

76.8

2.21

   3735

structural constituent of ribosome

15

100

2.65

   46872

metal ion binding

153

75.7

2.63

   43167

ion binding

154

75.1

2.43

   43169

cation binding

140

75.3

2.32

   3676

nucleic acid binding

129

75.4

2.25

   46914

transition metal ion binding

103

76.3

2.17

   35091

phosphoinositide binding

10

100

2.16

   8270

zinc ion binding

94

76.4

2.09

   4930

G-protein coupled receptor activity

9

100

2.05

   16023

cytoplasmic membrane-bound vesicle

11

100

2.27

   5830

cytosolic ribosome (sensu Eukaryota)

11

100

2.27

   5578

proteinaceous extracellular matrix

23

88.5

2.23

   31012

extracellular matrix

23

88.5

2.23

   5840

ribosome

15

93.8

2.20

   5842

cytosolic large ribosomal subunit (sensu Eukaryota)

10

100

2.16

   15934

large ribosomal subunit

10

100

2.16

   44420

extracellular matrix part

9

100

2.05