GOID | Pathway Name/GO Term | NO. genes | % Changed | Z-score |
---|---|---|---|---|
Up-regulated in overexpression and down-regulated in KD | ||||
   43549 | regulation of kinase activity | 12 | 60 | 2.73 |
   45859 | regulation of protein kinase activity | 12 | 60 | 2.73 |
   165 | MAPKKK cascade | 8 | 66.7 | 2.60 |
   51338 | regulation of transferase activity | 12 | 57.1 | 2.51 |
   65008 | regulation of biological quality | 15 | 53.6 | 2.51 |
   22402 | cell cycle process | 21 | 47.7 | 2.32 |
   1525 | angiogenesis | 8 | 61.5 | 2.31 |
   6952 | defense response | 13 | 52 | 2.19 |
   6508 | proteolysis | 12 | 52.2 | 2.12 |
   48514 | blood vessel morphogenesis | 8 | 57.1 | 2.04 |
   7264 | small GTPase mediated signal transduction | 10 | 52.6 | 1.96 |
   5515 | protein binding | 108 | 36.9 | 2.38 |
   5525 | GTP binding | 9 | 60 | 2.36 |
   30246 | carbohydrate binding | 10 | 55.6 | 2.18 |
   19001 | guanyl nucleotide binding | 9 | 56.3 | 2.11 |
   5783 | endoplasmic reticulum | 15 | 48.4 | 2.01 |
Down-regulated in overexpression and up-regulated in KD | ||||
   6066 | alcohol metabolic process | 14 | 100 | 2.56 |
   45449 | regulation of transcription | 95 | 77.9 | 2.45 |
   9719 | response to endogenous stimulus | 17 | 94.4 | 2.40 |
   6974 | response to DNA damage stimulus | 17 | 94.4 | 2.40 |
   19219 | regulation of nucleobase\, nucleoside\, nucleotide and nucleic acid metabolic process | 95 | 77.2 | 2.30 |
   7420 | brain development | 11 | 100 | 2.27 |
   6355 | regulation of transcription\, DNA-dependent | 89 | 77.4 | 2.25 |
   6350 | transcription | 96 | 76.8 | 2.21 |
   3735 | structural constituent of ribosome | 15 | 100 | 2.65 |
   46872 | metal ion binding | 153 | 75.7 | 2.63 |
   43167 | ion binding | 154 | 75.1 | 2.43 |
   43169 | cation binding | 140 | 75.3 | 2.32 |
   3676 | nucleic acid binding | 129 | 75.4 | 2.25 |
   46914 | transition metal ion binding | 103 | 76.3 | 2.17 |
   35091 | phosphoinositide binding | 10 | 100 | 2.16 |
   8270 | zinc ion binding | 94 | 76.4 | 2.09 |
   4930 | G-protein coupled receptor activity | 9 | 100 | 2.05 |
   16023 | cytoplasmic membrane-bound vesicle | 11 | 100 | 2.27 |
   5830 | cytosolic ribosome (sensu Eukaryota) | 11 | 100 | 2.27 |
   5578 | proteinaceous extracellular matrix | 23 | 88.5 | 2.23 |
   31012 | extracellular matrix | 23 | 88.5 | 2.23 |
   5840 | ribosome | 15 | 93.8 | 2.20 |
   5842 | cytosolic large ribosomal subunit (sensu Eukaryota) | 10 | 100 | 2.16 |
   15934 | large ribosomal subunit | 10 | 100 | 2.16 |
   44420 | extracellular matrix part | 9 | 100 | 2.05 |