Skip to main content

Table 1 Common cytokine-independent gene expression changes in T. cruzi-infected cells.

From: Cytokine-dependent and–independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling

Name

Sequence Description

Accession

HFF Fold

HFF

p-value

HMVEC Fold

HMVEC

p-value

VSMC Fold*

VSMC

p-value*

IFNB1

Interferon, beta 1, fibroblast

 

100

0.00E+00

98.6

4.50E-27

11.4

3.11E-06

CCL5

Chemokine (C-C motif) ligand 5

AF043341

71.0

9.13E-35

57.1

4.53E-19

36

5.38E-19

CCL5

Chemokine (C-C motif) ligand 5

M21121

35.9

4.30E-16

58.2

4.53E-08

36.7

2.23E-15

CCL5

Chemokine (C-C motif) ligand 5

 

33.5

1.96E-25

92.0

8.48E-16

27.4

1.00E-13

LOC126520

Hypothetical protein

AK054808

27.9

9.07E-18

11.4

8.23E-14

6.7

3.00E-05

215941_at

MRNA, Xq terminal portion

D16471

10.6

8.07E-07

9.1

8.84E-14

9.9

4.30E-08

LOC400740

Hypothetical gene

AW205774

10.4

6.68E-11

5.1

1.08E-03

6

8.50E-04

ZBTB7A

Zinc finger and BTB domain containing 7A

AI568395

8.8

3.20E-15

17.3

8.61E-19

11

6.11E-06

SSH2

Slingshot homolog 2 (Drosophila)

AB072358

8.4

5.85E-10

8.5

8.02E-08

5.6

1.57E-03

CARKL

Homo sapiens carbohydrate kinase-like (CARKL)

 

8.4

4.72E-08

9.0

4.64E-08

4.5

6.80E-03

1565716_at

GN0053 Homo sapiens cDNA, mRNA sequence.

BE930017

7.9

3.38E-18

10.1

2.29E-14

4.2

3.00E-05

SLC24A4

SLC family 24 (sodium/potassium/calcium exchanger), member 4

W90718

7.4

1.02E-08

4.7

2.95E-06

5.9

5.20E-04

LOC283761

Hypothetical protein

BC039350

6.5

3.30E-04

15.3

2.20E-08

11

4.57E-06

SYTL3

Synaptotagmin-like 3

AI990716

6.5

1.47E-06

4.8

1.00E-05

4.3

4.67E-03

FLJ35390

Hypothetical protein

BC024303

6.4

2.22E-10

6.2

3.83E-07

2.8

3.35E-03

IL17RE

Similar to contains element TAR1 repetitive element

AW003256

6.1

1.45E-06

3.4

2.74E-03

4.7

8.01E-03

SIM2

Single-minded (Drosophila) homolog 2 short isoform

 

5.8

7.69E-03

7.1

8.47E-06

6.8

1.48E-03

FLJ14213

Hypothetical protein

AV732741

4.8

4.02E-03

6.6

2.50E-04

10.3

1.10E-04

231673_at

Transcribed locus

AW273730

4.7

7.94E-06

5.6

3.00E-05

2.7

7.29E-03

TSNARE1

T-SNARE domain containing 1

AI741779

4.6

7.19E-13

3.5

8.00E-05

3.8

3.00E-05

234510_at

cDNA clone DKFZp566F133

AL049357

4.0

6.70E-04

4.2

9.00E-05

4.7

3.71E-03

PANK2

Pantothenate kinase 2

AV703394

3.5

9.91E-08

3.7

2.78E-03

2.1

7.06E-03

B3GNT2

beta-1,3-N-acetylglucosaminyltransferase

 

3.4

2.77E-09

2.9

3.56E-03

2.1

3.00E-05

241657_at

Transcribed locus

AI791835

3.3

1.21E-03

4.4

8.50E-04

3.7

8.99E-03

STIM1

Stromal interaction molecule 1

BC016014

3.1

2.30E-04

3.9

1.51E-08

2.6

4.81E-03

KLF4

Kruppel-like factor 4

BF514079

3.1

1.74E-08

8.2

1.04E-03

3.4

2.20E-07

HIST1H2AJ

H2A histone family, member E

 

3.1

1.22E-09

4.7

1.85E-09

2.1

2.40E-04

HIST1H2AI

H2A histone family, member C

 

3.0

2.69E-07

4.9

5.39E-08

2.1

4.60E-04

FNDC3A

Cytochrome c oxidase subunit VIIc pseudogene 1

AL137000

2.8

5.61E-08

2.2

2.59E-03

2.3

4.03E-06

B4GALT5

beta 1,4-galactosyltransferase polypeptide 5

AL035683

2.8

4.55E-24

2.0

1.60E-10

2.1

2.38E-08

SPP1

Secreted phosphoprotein 1 (osteopontin)

M83248

2.6

6.17E-03

5.1

1.80E-04

3.1

4.40E-04

CD55

Decay accelerating factor for complement

 

2.5

2.00E-05

2.2

9.37E-06

2.2

2.05E-06

LYSMD2

LysM, putative peptidoglycan-binding, domain containing 2

AI674731

2.1

3.00E-05

3.5

3.58E-25

2.9

1.00E-05

PTPN11

Protein tyrosine phosphatase, non-receptor type 11

L07527

-2.3

7.47E-03

-5.2

7.40E-04

-2.2

1.04E-03

PKP4

Plakophilin 4

 

-2.5

4.14E-08

-2.4

4.80E-04

-2

1.60E-07

MGC52110

hypothetical protein MGC52110

BF195431

-4.0

1.01E-06

-4.9

7.67E-06

-2.3

4.33E-03

MYT1

Myelin transcription factor 1

AB028973

-5.3

2.37E-16

-4.4

6.57E-06

-2.1

5.52E-03

  1. Gene expression changes occurring in human vascular smooth muscle cells 24 hours after infection with T. cruzi. The data shown corresponds to probes for transcripts showing an intensity increase of 2-fold or greater (p < 0.01) with respect to their matched controls according to the analysis with Rosetta Resolver Biosoftware 7.0. *Transwell data not available for VSMC.