The gene RE frequencies in the cell cycle pathway. The gene up-RE frequencies at each HCC stage are mapped as a grid on the cell cycle pathway (KEGG: hsa04110) by using a public software PathwayExplorer . In a grid, columns represent very early (VE), early (E), advance (A) and very advance (VA) HCCs, respectively. Rows represent genes annotated with the identical function in the pathway. The representative gene names are labeled in the center of the grids.