Skip to main content

Table 3 Selected Gene Ontology GO categories significantly affected by genes deregulated following IL-2 deprivation.

From: Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal

GO category GO categories GO term LS permutation p-value KS permutation p-value Efron-Tibshirani's GSA test
p-value
Up-regulated genes
(p < 0.01)
Down-regulated genes
(p < 0.01)
GO:0004907 MF interleukin receptor activity 0.00001 0.00001 < 0.005 IL12RB1, IL7R IL2RA, IL12RB2, IL17RB IL1RAP
GO:0019955 MF cytokine binding 0.00001 0.00001 < 0.005 IL12RB1, IL7R IL2RA, IL12RB2, IL17RB IL1RAP
GO:0004896 MF hematopoietin/interferon-class (D200-domain) cytokine receptor activity 0.00001 0.0000988 < 0.005 IL12RB1, IL7R IL2RA, IL12RB2, IL17RB IL1RAP
GO:0007259 BP JAK-STAT cascade 0.00001 0.0001056 < 0.005   SOCS1, SOCS2, SOCS3, OSM, STAT4
GO:0006959 BP humoral immune response 0.00001 0.0006364 < 0.005   BCL2, CD55, CFHR1, TNF, LTA, CFH, BCL3, GPI
GO:0050900 BP leukocyte migration 0.00001 0.0047229 < 0.005 MYH9 IL8, TNF, CKLF, ITGB2
GO:0017040 MF ceramidase activity 0.00001 0.0049829 < 0.005 ASAH1  
GO:0018108 BP peptidyl-tyrosine phosphorylation 0.0001871 0.0032075 < 0.005 CLK4 OSM, SOCS1, IL5, ITGB2
GO:0006672 BP ceramide metabolic process 0.0004208 0.0030228 < 0.005 ASAH1 UGCG, CLN8
GO:0007260 BP tyrosine phosphorylation of STAT protein 0.0004601 0.0046325 < 0.005   OSM, SOCS1
GO:0030218 BP erythrocyte differentiation 0.0013289 0.00001 < 0.005 FOXO3, BCL6 SFXN1
GO:0042379 MF chemokine receptor binding 0.001562 0.0008411 < 0.005   IL8, CCL3, CKLF
GO:0048660 BP regulation of smooth muscle cell proliferation 0.003213 0.0021998 < 0.005   HBEGF
  1. Three independent tests: LS, KS and Efron-Tibshirani GSA were applied to select significantly affected gene classes.