Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal

BMC Genomics

Table 3 Selected Gene Ontology GO categories significantly affected by genes deregulated following IL-2 deprivation.

GO category	GO categories	GO term	LS permutation p-value	KS permutation p-value	Efron-Tibshirani's GSA test p-value	Up-regulated genes (p < 0.01)	Down-regulated genes (p < 0.01)
GO:0004907	MF	interleukin receptor activity	0.00001	0.00001	< 0.005	IL12RB1, IL7R	IL2RA, IL12RB2, IL17RB IL1RAP
GO:0019955	MF	cytokine binding	0.00001	0.00001	< 0.005	IL12RB1, IL7R	IL2RA, IL12RB2, IL17RB IL1RAP
GO:0004896	MF	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.00001	0.0000988	< 0.005	IL12RB1, IL7R	IL2RA, IL12RB2, IL17RB IL1RAP
GO:0007259	BP	JAK-STAT cascade	0.00001	0.0001056	< 0.005		SOCS1, SOCS2, SOCS3, OSM, STAT4
GO:0006959	BP	humoral immune response	0.00001	0.0006364	< 0.005		BCL2, CD55, CFHR1, TNF, LTA, CFH, BCL3, GPI
GO:0050900	BP	leukocyte migration	0.00001	0.0047229	< 0.005	MYH9	IL8, TNF, CKLF, ITGB2
GO:0017040	MF	ceramidase activity	0.00001	0.0049829	< 0.005	ASAH1
GO:0018108	BP	peptidyl-tyrosine phosphorylation	0.0001871	0.0032075	< 0.005	CLK4	OSM, SOCS1, IL5, ITGB2
GO:0006672	BP	ceramide metabolic process	0.0004208	0.0030228	< 0.005	ASAH1	UGCG, CLN8
GO:0007260	BP	tyrosine phosphorylation of STAT protein	0.0004601	0.0046325	< 0.005		OSM, SOCS1
GO:0030218	BP	erythrocyte differentiation	0.0013289	0.00001	< 0.005	FOXO3, BCL6	SFXN1
GO:0042379	MF	chemokine receptor binding	0.001562	0.0008411	< 0.005		IL8, CCL3, CKLF
GO:0048660	BP	regulation of smooth muscle cell proliferation	0.003213	0.0021998	< 0.005		HBEGF

Three independent tests: LS, KS and Efron-Tibshirani GSA were applied to select significantly affected gene classes.

ISSN: 1471-2164