Skip to main content

Table 4 A selection of significantly impacted pathways (BioCarta) in T lymphocytes following IL-2 deprivation.

From: Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal

Pathway description

Biocarta Pathway

LS permutation

p-value

KS permutation

p-value

Efron-Tibshirani's GSA test p-value

Up-regulated genes

(p < 0.01)

Down-regulated genes

(p < 0.01)

Visceral Fat Deposits and the Metabolic Syndrome

h_vobesityPathway

0.00001

0.0001273

< 0.005

NR3C1

TNF, HSD11B1

Cells and Molecules involved in local acute inflammatory response

h_LairPathway

0.00001

0.0007952

< 0.005

ITGB1, ITGAL

IL8, TNF, ICAM1, ITGA4

Adhesion and Diapedesis of Lymphocytes

h_lympathway

0.00001

0.0029985

< 0.005

ITGB1, ITGAL

IL8, ICAM1, ICAM2, ITGA4

Adhesion and Diapedesis of Granulocytes

h_granulocytesPathway

0.00001

0.0032844

< 0.005

 

IL-8, TNF, CD54, ICAM2

Cytokine Network

h_cytokinePathway

0.00001

0.0297027

< 0.005

 

IL13, IL8, LTA, IL-5

IL-2 Receptor Beta Chain in T cell Activation

h_il2rbPathway

0.00001

0.030315

< 0.005

 

CISH, IL2RA, SOCS3, BCL2, AKT1, JAK3

Induction of apoptosis through DR3 and DR4/5 Death Receptors

h_deathPathway

0.00001

0.00001

0.06

 

BCL2, TRADD

IL22 Soluble Receptor Signaling Pathway

h_il22bppathway

0.0000955

0.00001

< 0.005

 

SOCS3, JAK3

Selective expression of chemokine receptors during T-cell polarization

h_nktPathway

0.0000994

0.0000936

0.03

IL12RB1, CCR4

ILRB2, CCL3, IL5

Cytokines and Inflammatory Response

h_inflamPathway

0.0001717

0.078942

< 0.005

 

IL13, IL8, TNF, LTA, IL5

NO2-dependent IL 12 Pathway in NK cells

h_no2il12Pathway

0.0006013

0.0135205

< 0.005

IL12RB1, CD2

IL12RB2

Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases

h_dspPathway

0.0007988

0.1717258

< 0.005

 

DUSP6, DUSP1

PTEN dependent cell cycle arrest and apoptosis

h_ptenPathway

0.0015749

0.0100088

< 0.005

FOXO3, ITGB1, MAPK1

AKT1, PDK1, SOS1

Ceramide Signaling Pathway

h_ceramidePathway

0.0016286

0.005673

< 0.005

MAPK1

BCL2, TRADD

Th1/Th2 Differentiation

h_th1th2Pathway

0.001734

0.0676275

0.07

IL12RB1

IL2RA, IL12RB2

Dendritic cells in regulating TH1 and TH2 Development

h_dcPathway

0.0023595

0.0493208

< 0.005

  

p53 Signaling Pathway

h_p53Pathway

0.0026524

0.1802796

< 0.005

 

BCL2, CDK2, CDKN1A

Telomeres, Telomerase, Cellular Aging, and Immortality

h_telPathway

0.0367325

0.3499152

< 0.005

 

BCL2, AKT1

Phospholipids as signalling intermediaries

h_edg1Pathway

0.0404929

0.1894782

< 0.005

ASAH1

AKT1

  1. Testing of 288 Biocarta human pathways identified 54 out of 288 investigated gene-sets that passed the 0.005 significance threshold in at least one test (38 gene-sets in LS/KS test and 36 in Efron-Tibshirani's test).
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us