Skip to main content
Figure 2 | BMC Genomics

Figure 2

From: Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

Figure 2

Molecular mechanism of compensation at COIII. (A) Transmembrane structure highlighting the deleterious Leu251 at the C-terminus region and sequence comparison between human and primate species harboring the mutation and the most likely candidate to compensatory site. (B) Three-dimensional model of human cytochrome oxidase c complex showing positions Phe251 and Val254 at COIII. (C) H-bonding interactions between Phe251 and Val254 in the wild-type background. (D) Deleterious background (Leu251-Val254) showing a de novo interaction with Ser255. (E) Compensated background (Leu251-Ile254) illustrating the reestablishment of the original bonding pattern.

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us