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Table 1 Human deleterious mutations at mitochondrial-encoded proteins present as wild-type amino acid in mammalian orthologues.

From: Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

Protein

Human mutation

(associated phenotype)

Non-human mutation carriers

COI (Cytochrome c oxidase subunit I)

Leu196Ile

(Epilepsy)

Order: Rodentia

Family: Gliridae

Species: Myoxus glis (Fat dormouse)

COIII (Cytochrome c oxidase subunit III)

Phe251Leu

(Encephalopathy/MELAS)

Order: Primates

Family: Cercopithecidae

Species: Chlorocebus aethiops (African green monkey); Chlorocebus tantalus (Tantalus monkey);Chlorocebus sabaeus (Green monkey); Chlorocebus pygerythrus (Vervet monkey); Semnopithecus entellus (Hanuman langur); Macaca mulatta (Rhesus monkey); Macaca sylvanus (Barbary ape)

CYB (Cytochrome b)

Gly251Ser

(Exercise intolerance)

Order: Primates

Family: Hominidae

Species: Pongo pygmaeus (Bornean orangutan);Pongo abelii (Sumatran orangutan)

  

Order: Primates

Family: Cercopithecidae

Species: Macaca sylvanus (Barbary ape);Colobus guereza (Guereza);Trachypithecus obscures (Dusky leaf monkey);Rhinopithecus roxellana (Golden snub-nosed monkey);Presbytis melalophos

(Mitred leaf monkey);Procolobus badius (Western red colobus);Semnopithecus entellus (Hanuman langur)

  

Order: Diprotodontia

Family: Phalangeridae

Species: Trichosurus vulpecula (Silver-gray brushtail possum)

  

Order: Diprotodontia

Family: Phascolarctidae

Species: Phascolarctos cinereus (Koala)