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Table 4 Major known genes by functional class in the L3i gene set

From: Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3

Functional class

Gene

Oligo ID

Fold

NCBI accession number and description

Immunomodulators

alt-1

BMC00123

35

AAB03902.2| Av18, Alt 1 variant

 

alt-2 (2)

14863.m00021

20

AAF01224.1| Alt2 variant

 

cpi-1 (3)

BMC12220

41

AAD51085.1| cystatin-type cysteine proteinase inhibitor CPI-1

 

cpi-2 (2)

BMW01194

4

AAD51086.1| cystatin-type cysteine proteinase inhibitor CPI-2

 

spn-1 (5)

AA840996

20

AAB42377.1| BmSERPIN

Anti-oxidants

gst (1)

BMC02401

2.6

CAA73325.1| glutathione transferase

detoxification

sod (3)

BMC00677

2.2

AAR06638.1| superoxide dismutase

 

akr (1)

AA841533

15.4

NP_509242.1| (Aldo/keto reductase family proteins)

 

grx (1)

13358.m00042

4.2

CAE74325.1| Glutaredoxin-like region

 

tpx-1 (1)

TC2998

11.2

AAN34969.1| thioredoxin 1; ov-thioredoxin 1

 

tpx-1 ( 3)

BMC12191

2.4

AAL91107.1| thioredoxin

 

tpx-2 (1)

BMC12241

3.7

Q17172|TDX2hioredoxin peroxidase 2

 

trxR (1)

14972.m07078

4.3

AAD46625.1| thioredoxin reductase homolog

 

pxn-2 (1)

BMC12240

4.3

AAC77922.1| peroxidoxin-2

Proteases

cpl-1 ( 7)

BMC01348

10.7

AAK16513.1|cathepsin L-like cysteine proteinase

 

cpl-4 ( 4)

BMC06080

20.8

AAT07057.1| cathepsin L-like cysteine proteinase

 

cpl-5 (2)

BMC11984

19.7

AAT07058.1| cathepsin L-like cysteine proteinase

 

mtp (1)

BMC10914

4.6

BAC66058.1| matrix metalloproteinase

Pathogenesis

val-1 (7)

BMC12291

10

gb|AAB97283.2| vespid allergen antigen homolog

related protein

nlt-1

BMC12455

7.5

AAD11970.1| 24 kDa secreted protein

Parasitism

ov103

12584.m00062

13.6

AAA63412.2| microfilariae surface-associated

  

BMC01088

3.2

AAF76925.1|1 hypothetical esophageal gland cell secretory protein 11

Stress resistant

shsp

TC3642

10.2

AAB07020.1| small heat shock protein

Cuticular components

elo-3

14954.m01636

58.2

ref|NP_501147.2| fatty acid ELOngation family member (elo-3)

Related member

col (47)

TC2764

11.2

NP_500520.1| COLlagen family member (col-34)

 

Grl-4

14083.m00057

8.9

NP_501166.2| GRound-Like (grd related) family member (grl-4)

Highly immunogenic

Val (8)

BMC12291

9.9

aaB97283.2 vespid allergen antigen homolog

 

(3)

WB-contig_1280

10.8

AAA63412.2| microfilariae surface-associated

 

(1)

BMC07029

2.8

P23730|IFEA_ASCSU Intermediate filament protein A

 

(3)

14323.m00082

7.1

AAN62757.1| larval allergen [Brugia malayi]

 

spx-1 (4)

BMC05831

6.1

AAA27864.1| SPX-1

 

(2)

BMC02375

3.6

AAC48290.1| Gln-rich protein

  1. Numbers in parentheses represent the number of oligos that match a particular gene that was upregulated.