Over- and under-expressed host genes across time in infected cells compared to non-infected ones. (A) Venn diagram showing the repartition of the differentially expressed host transcripts at the 4 time points in malaria infected vs. non infected cells. The intersections show the number of probesets present in more than 1 time point. The numbers within separated ellipses correspond to differentially expressed genes that are unique to each time point. (B) Number of genes DE for each time point after normalisation and linear model fitting. Genes with more than one DE probeset presenting a consistent fold change were counted. Up- and down-regulated genes are shown in red and blue, respectively. The y-axis represents the number of differentially expressed genes (DEG). (C) Heatmap comparing the genes significantly altered between P. berghei infected cells vs. non infected ones. Each row of the plot is a gene and was coloured according to the log2 ratio of expression, with red meaning up-regulation in infected cells relative to the non-infected ones and blue meaning down-regulation. The heatmaps were generated using the heatmap.2 function of the "gplots" package in R. The dendrograms were generated using Euclidean distance and "complete" agglomeration method. The 3D PCA was generated using "scatterplot3d" package in R.